急性和慢性感染的生物膜形成,特别强调常见的慢性和医院感染

Q3 Pharmacology, Toxicology and Pharmaceutics
Parama Das Gupta, Upal Das Ghosh, Rini Roy
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引用次数: 0

摘要

生物膜被定义为附着在活体或非活体固体表面并嵌入由胞外多糖材料组成的共同自制基质中的微生物群落。生物膜在慢性疾病中的作用值得特别重视,因为这些细胞外聚合材料与群体感应一起发展,支持感染发展的主要标准,即粘附和定植。生物膜中存在的微生物由于其结构和生理上的变化,难以治疗或根除。细胞外聚合物保护层的存在、代谢活动的变化或高突变率使它们对常规治疗具有耐受性或抗性。病原微生物的持续存在使生物膜与几种急性和慢性感染以及各种医院或医疗保健相关感染有关。此外,生物膜的形成也可能导致癌症的发展。生物膜可能导致炎症。本研究涉及生物膜形成的分子方面及其在不同疾病形成中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biofilm Formation in Acute and Chronic Infections with Special Emphasis on Common Chronic and Nosocomial Infections
Biofilm is defined as a community of microorganisms that are adhered to living or non-living solid surfaces and embedded in a common, self-made matrix, comprising of exopolysaccharide material. The role of biofilm in chronic diseases deserves special importance as these extracellular polymeric materials developed with quorum sensing support both the primary criteria of infection development namely adhesion and colonisation. Due to their structural and physiological changes, microorganisms present in the biofilm are difficult to treat or eradicate. The presence of a protective layer of extracellular polymers, changes in metabolic activity or a high rate of mutation make them tolerant or resistant to conventional treatment. The persistence of pathogenic microorganisms mostly renders biofilm to be associated with several acute and chronic infections and various nosocomial or healthcare-related infections. Furthermore, cancer development may also result due to biofilm formation. Biofilm may contribute to inflammation. This study deals with molecular aspects of biofilm formation and its role in different disease formations.
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来源期刊
Defence Life Science Journal
Defence Life Science Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
0.80
自引率
0.00%
发文量
26
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