印度尼西亚两处保护产地悬挑果中花青素抗代谢活性的研究

IF 0.7 Q4 PHARMACOLOGY & PHARMACY
Ana Yulyana, Chaidir Amin, Partomuan Simanjuntak, Syamsudin Abdillah, Abdul Rohman, Eko Mugiyanto
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引用次数: 0

摘要

本研究的目的是评价来自印度尼西亚两个保护区的悬臂果中花青素的抗代谢活性。悬臂(vacinium varingiaefolium)是一种本地水果,以其丰富的花青素含量而闻名,具有多种健康益处。然而,这些花青素的抗代谢特性还需要进行更多的研究。本研究收集了印度尼西亚两个保护区Tangkuban Perahu (CTP)和Papandayan (CPP) Mountain的悬提果,并采用酶促法对其抗代谢活性进行了评价。结果表明,CTP对α-葡萄糖苷酶(53.72±1.98µg/ml)、胰脂肪酶(110.48±2.13µg/ml)和血管紧张素转换酶(27.32±1.24µg/ml)的抑制作用显著。此外,我们利用HRMS分析发现了三种花青素化合物,飞鸡苷,马柳苷和牡丹苷,这些化合物被认为是观察到的抗代谢活性的一部分。这些发现提供了有价值的见解,具体化合物负责的生物活性的悬臂和进一步支持其作为生物活性物质的天然来源的潜力。未来的研究应集中于阐明这些花青素作用于目标酶的分子机制,并探索它们之间潜在的协同作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessing the Antimetabolite Activity of Anthocyanins in Cantigi Fruits from Two Conservation Sites in Indonesia
The objective of the current study was to evaluate the antimetabolite activity of anthocyanins in Cantigi fruits from two Indonesian conservation areas. Cantigi (Vaccinium varingiaefolium) is a native fruit species known for its rich anthocyanin content associated with various health benefits. However, more research needs to be conducted on the antimetabolite properties of these anthocyanins. This study collected Cantigi fruits from two conservation sites in Indonesia, Tangkuban Perahu (CTP) and Papandayan (CPP) Mountain, and the antimetabolite activity was evaluated using enzymatic assays. The results demonstrated significant antimetabolite activity of CTP, particularly in inhibiting α-Glucosidase (53.72±1,98 µg/ml), pancreatic lipase (110.48±2,13 µg/ml), and angiotensin-converting enzyme (27.32±1,24 µg/ml). Furthermore, our analysis using HRMS revealed the presence of three anthocyanin compounds, delphinidin, malvidin, and peonidin, which are believed to contribute to the observed antimetabolite activities of Cantigi. These findings provide valuable insights into the specific compounds responsible for the bioactivity of Cantigi and further support its potential as a natural source of bioactive substances. Future research should focus on elucidating the molecular mechanisms underlying the effects of these anthocyanins on the targeted enzymes and exploring their potential synergistic interactions.
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来源期刊
INDONESIAN JOURNAL OF PHARMACY
INDONESIAN JOURNAL OF PHARMACY PHARMACOLOGY & PHARMACY-
CiteScore
1.20
自引率
0.00%
发文量
38
审稿时长
12 weeks
期刊介绍: The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education. The journal includes various fields of pharmaceuticals sciences such as: -Pharmacology and Toxicology -Pharmacokinetics -Community and Clinical Pharmacy -Pharmaceutical Chemistry -Pharmaceutical Biology -Pharmaceutics -Pharmaceutical Technology -Biopharmaceutics -Pharmaceutical Microbiology and Biotechnology -Alternative medicines.
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