Evaluate the Levels of Lysophosphatidic Acid and Lipid Profile in Patients with Breast Cancer

The current study aims to evaluate the levels of lysophosphatidic acid-LPA and lipid profile in sera of women with breast cancer-BC. Ninety serum samples were taken from women; 30 samples were taken from healthy women (control group-C) without a history of BC, and 60 samples were divided into two groups: 30 untreated BC patients as first group-G1, and 30 post-treatment as the second group-G2. The study includes the determination of the level of serum LPA, total cholesterol-TC, triglycerides-TG, high-density lipoprotein-HDL, low-density lipoprotein-LDL and very low-density lipoprotein-VLDL. The results indicate that the value of body mass index-BMI was significantly higher in G1 as compared with G2 and the control group. The level of LPA and HDL was significantly elevated in the patients' group, while the levels of serum TC, TG, LDL, VLDL and TC/HDL ratio were significantly decreased in the patients' groups(G1 and G2) as compared with C. From the results of the current study, we can conclude that LPA plays an important role in the development of BC in new diagnostic cases or after treatment, while the correlation between lipids and breast cancer is obscure and needs more studies.