朗格卢瓦试剂氧化三氟甲基化光诱导合成2-三氟甲基化吲哚

IF 2.2 4区化学 Q2 CHEMISTRY, ORGANIC

Synthesis-Stuttgart Pub Date : 2023-10-05 DOI:10.1055/s-0040-1720093

Deepak K. Sharma, Samarpita Das, Harish K. Indurthi, Amita Kumari

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引用次数: 0

摘要

摘要在无外部光激活剂的条件下，在紫外光照射(360 ~ 365 nm)下，用CF3SO2Na光诱导吲哚的C-2三氟甲基化反应。关键步骤是在氧气或空气和紫外线照射下将CF3SO2Na试剂原位转化为CF3•自由基。该方法具有反应条件温和、底物耐受性好、克级可扩展性好等优点。

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Photoinduced Synthesis of 2-Trifluoromethylated Indoles through Oxidative Trifluoromethylation Using Langlois’ Reagent in the Absence of External Photocatalyst

Abstract A photoinduced approach for regioselective C-2 trifluoromethylation of indoles was achieved with CF3SO2Na under UV light irradiation (360–365 nm) at ambient conditions without any external photo activator. The key steps involve the in situ conversion of CF3SO2Na reagent to CF3 • radical under oxygen or air and UV irradiation. This proficient method has the advantages of mild reaction conditions, fair substrate tolerability, and gram scalability.

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来源期刊

Synthesis-Stuttgart 化学-有机化学

CiteScore

4.50

自引率

7.70%

发文量

435

审稿时长

1 months

期刊介绍： SYNTHESIS is an international full-paper journal devoted to the advancement of the science of chemical synthesis. It covers all fields of organic chemistry involving synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines. SYNTHESIS provides dependable research results with detailed and reliable experimental procedures and full characterization of all important new products as well as scientific primary data.