ALDH1在结直肠腺瘤伴低/高级别不典型增生和癌中的评价及临床病理相关性

IF 0.6 Q4 ONCOLOGY
Himanshi Bhanu, Ruchi Mittal, Urmila Senapati
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引用次数: 0

摘要

结直肠癌(CRC)是最常见的恶性肿瘤之一,具有显著的发病率和死亡率。在结直肠癌发生过程中,癌症干细胞被认为是关键因素,为肿瘤注入侵袭性特征,包括化疗耐药性。一组被称为ALDH1的酶表现出干细胞特性,可能在结直肠肿瘤中发挥作用。本研究旨在探讨ALDH1在结肠肿瘤中的表达及其与临床病理参数的关系。该研究包括2019年9月至2021年8月前瞻性收集的50例连续病例,包括结直肠癌(30例)和结直肠腺瘤(20例),以及2018年1月至2019年8月的存档病例。对结直肠癌病例进行组织学检查,评估肿瘤类型、分级、淋巴血管侵犯、神经周围侵犯、有丝分裂、坏死,对结直肠腺瘤进行组织学分级。对结直肠癌和腺瘤标本进行ALDH1免疫组化。统计分析采用SPSS 20软件,采用卡方检验和Fischer精确检验。与癌相比,腺瘤的阳性染色率较高(p = 0.0005),表达率较高(p = 0.036)。其他临床病理参数无明显相关性。低级别非典型增生腺瘤的ALDH1阳性染色和表达频率高于高级别非典型增生腺瘤。在恶性病例中,与高分期疾病相比,低分期疾病中观察到较高比例的阳性染色。ALDH1在腺瘤和癌中的高染色和表达结果,以及它们在低期癌中的存在,表明在疾病进展过程中可能获得新的突变和不同克隆干细胞亚群的增殖。腺瘤/癌中ALDH1的缺失可能预示着较差的预后和疾病进展到更高阶段的可能性增加。需要全面的多机构和验证性研究来增强我们对ALDH1在结直肠癌发生中的作用的理解,以及它作为靶向或个性化治疗选择的可行性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation and Clinicopathological Correlation of ALDH1 in Colorectal Adenoma with Low-/High-Grade Dysplasia and Carcinoma.
Colorectal carcinoma (CRC) stands as one of the most prevalent malignant neoplasms, carrying significant morbidity and mortality implications. Within colorectal carcinogenesis, cancer stem cells are recognized as key contributors, infusing tumors with aggressive traits, including chemoresistance. A group of enzymes known as ALDH1 exhibits stem cell properties, potentially playing a role in colorectal neoplasms. This study aims to evaluate ALDH1 expression in colonic neoplasms and its correlation with clinicopathological parameters. The research encompasses 50 consecutive cases, involving CRC (30) and colorectal adenoma (20), gathered prospectively from September 2019 to August 2021, as well as archived cases from January 2018 to August 2019. Histological examination was conducted on CRC cases to assess tumor type, grade, lymphovascular invasion, perineural invasion, mitosis, and necrosis, while colorectal adenomas were subjected to histological grading. ALDH1 immunohistochemistry was performed on both CRC and adenoma specimens. Statistical analysis utilized SPSS 20 software, employing the chi-squared test and Fischer's exact test. A higher count of adenoma cases displayed positive staining (p = 0.0005) and greater expression (p = 0.036) in comparison to carcinoma cases. The other clinicopathological parameters didn't demonstrate notable associations. Adenomas with low-grade dysplasia exhibited a higher frequency of positive ALDH1 staining and expression than those with high-grade dysplasia. In malignant cases, a higher proportion of positive staining was observed in lower-stage disease compared to higher-stage disease. The heightened staining and expression outcomes of ALDH1 in adenomas versus carcinomas, as well as their presence in lower-stage carcinomas, suggest the potential acquisition of novel mutations and the proliferation of distinct clonal stem cell subsets during disease progression. The absence of ALDH1 in adenoma/carcinoma could indicate a poorer prognosis and an increased likelihood of disease progression to a higher stage. Comprehensive multi-institutional and validation studies are needed to enhance our understanding of ALDH1's role in colorectal oncogenesis, as well as its viability as a targeted or personalized therapy option.
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CiteScore
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自引率
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发文量
80
审稿时长
35 weeks
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