Gabriela Lucena de Almeida Oliveira , Eduardo Jorge Abrantes da Fonte , Maria Eduarda da Costa Brandão Justino , Leuridan Cavalcante Torres
{"title":"老年衰弱综合征患者的B细胞和T细胞亚群","authors":"Gabriela Lucena de Almeida Oliveira , Eduardo Jorge Abrantes da Fonte , Maria Eduarda da Costa Brandão Justino , Leuridan Cavalcante Torres","doi":"10.1016/j.tma.2023.10.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Aging is related to changes in functional reserve that progressively lead to increased morbidity and mortality. Frailty syndrome, a common entity in older adults, is characterized by increased vulnerability to stress secondary to a decline in homeostasis caused by dysregulation.</p></div><div><h3>Objective</h3><p>The study aimed to evaluate the immunocompetence of elderly individuals with frailty syndrome.</p></div><div><h3>Methods</h3><p>A cross-sectional and translational study was carried with sixty-nine older adults with frailty syndrome (patients) and 42 healthy older adults (controls) were included.</p></div><div><h3>Results</h3><p>Low naive TCD4+ cells (P = 0.03) in patients with Frailty syndrome compared to controls. Low levels of total T cells (P = 0.01), TCD4+ (P = 0.005), and TCD4+/TCD8+ ratio (P = 0.04), memory T cells (P = 0.02), memory TCD4+ (P = 0.001), memory T CD8<sup>+</sup> (P < 0.0001), and high levels of naïve/memory T cells ratio (p = 0.008) in Frailty syndrome patients with age ≥70 years.</p></div><div><h3>Conclusion</h3><p>Older adults with frailty syndrome have alterations in the cellular immune response, and these findings may be associated with increased morbidity and mortality in these patients.</p></div>","PeriodicalId":36555,"journal":{"name":"Translational Medicine of Aging","volume":"7 ","pages":"Pages 118-127"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468501123000123/pdfft?md5=bbc3efc735287780cb5f1897f28338af&pid=1-s2.0-S2468501123000123-main.pdf","citationCount":"0","resultStr":"{\"title\":\"B and T cell subsets in elderly with frailty syndrome\",\"authors\":\"Gabriela Lucena de Almeida Oliveira , Eduardo Jorge Abrantes da Fonte , Maria Eduarda da Costa Brandão Justino , Leuridan Cavalcante Torres\",\"doi\":\"10.1016/j.tma.2023.10.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Aging is related to changes in functional reserve that progressively lead to increased morbidity and mortality. Frailty syndrome, a common entity in older adults, is characterized by increased vulnerability to stress secondary to a decline in homeostasis caused by dysregulation.</p></div><div><h3>Objective</h3><p>The study aimed to evaluate the immunocompetence of elderly individuals with frailty syndrome.</p></div><div><h3>Methods</h3><p>A cross-sectional and translational study was carried with sixty-nine older adults with frailty syndrome (patients) and 42 healthy older adults (controls) were included.</p></div><div><h3>Results</h3><p>Low naive TCD4+ cells (P = 0.03) in patients with Frailty syndrome compared to controls. Low levels of total T cells (P = 0.01), TCD4+ (P = 0.005), and TCD4+/TCD8+ ratio (P = 0.04), memory T cells (P = 0.02), memory TCD4+ (P = 0.001), memory T CD8<sup>+</sup> (P < 0.0001), and high levels of naïve/memory T cells ratio (p = 0.008) in Frailty syndrome patients with age ≥70 years.</p></div><div><h3>Conclusion</h3><p>Older adults with frailty syndrome have alterations in the cellular immune response, and these findings may be associated with increased morbidity and mortality in these patients.</p></div>\",\"PeriodicalId\":36555,\"journal\":{\"name\":\"Translational Medicine of Aging\",\"volume\":\"7 \",\"pages\":\"Pages 118-127\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2468501123000123/pdfft?md5=bbc3efc735287780cb5f1897f28338af&pid=1-s2.0-S2468501123000123-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Translational Medicine of Aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2468501123000123\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational Medicine of Aging","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468501123000123","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
B and T cell subsets in elderly with frailty syndrome
Background
Aging is related to changes in functional reserve that progressively lead to increased morbidity and mortality. Frailty syndrome, a common entity in older adults, is characterized by increased vulnerability to stress secondary to a decline in homeostasis caused by dysregulation.
Objective
The study aimed to evaluate the immunocompetence of elderly individuals with frailty syndrome.
Methods
A cross-sectional and translational study was carried with sixty-nine older adults with frailty syndrome (patients) and 42 healthy older adults (controls) were included.
Results
Low naive TCD4+ cells (P = 0.03) in patients with Frailty syndrome compared to controls. Low levels of total T cells (P = 0.01), TCD4+ (P = 0.005), and TCD4+/TCD8+ ratio (P = 0.04), memory T cells (P = 0.02), memory TCD4+ (P = 0.001), memory T CD8+ (P < 0.0001), and high levels of naïve/memory T cells ratio (p = 0.008) in Frailty syndrome patients with age ≥70 years.
Conclusion
Older adults with frailty syndrome have alterations in the cellular immune response, and these findings may be associated with increased morbidity and mortality in these patients.
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