(trans-3-Benzyloxycarbonylamino-1-methyl-3) - methylcarbamoyl azetidine-1-oxide

IF 0.6 Q4 CHEMISTRY, ORGANIC

Molbank Pub Date : 2023-09-15 DOI:10.3390/m1726

Dayi Liu, Régis Guillot, Sylvie Robin, David J. Aitken

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引用次数: 0

摘要

采用立体选择性氧化法制备了反式-3-苄基氧羰基氨基-1-甲基-3-(甲氨酰基)氮杂啶-1-氧化物。通过IR、1H-NMR和13C-NMR在低极性溶液中对稳定分子进行了表征，并通过x射线衍射在固态中与水共晶进行了表征。n -氧化物功能在溶液中与甲基酰胺NH形成分子内强的7元环氢键，在固态中与邻分子中的氨基甲酸酯NH形成分子间氢键。

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trans-3-Benzyloxycarbonylamino-1-methyl-3-(methylcarbamoyl)azetidine-1-oxide

trans-3-Benzyloxycarbonylamino-1-methyl-3-(methylcarbamoyl)azetidine-1-oxide was prepared by stereoselective oxidation of the corresponding azetidine precursor. The stable molecule was characterized in a low-polarity solution by IR, 1H-NMR and 13C-NMR, and in the solid state as a co-crystal with water by X-Ray diffraction. The N-oxide function made a strong intramolecular 7-membered ring hydrogen bond with the methyl amide NH in solution and formed an intermolecular H-bond with the carbamate NH in a neighboring molecule in the solid state.

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来源期刊

Molbank Chemistry-Physical and Theoretical Chemistry

CiteScore

0.70

自引率

33.30%

发文量

174

审稿时长

11 weeks

期刊介绍： •organic synthesis •biosynthesis •extraction and purification •natural product derivatives •structural elucidation (X-ray crystallography, NMR, etc.)