铜钙对抗结核药物致大鼠肝毒性的保护作用

IF 0.7 Q4 PHARMACOLOGY & PHARMACY

Pharmacognosy Research Pub Date : 2023-11-08 DOI:10.5530/pres.15.4.085

Mohammad Sharique, Hariprasad Hariprasad MG, Moqbel Ali Moqbel Redhwan, Ashish Jain, Shambhavi Shambhavi S, Mamatha Mamatha A, Niranjana Niranjana N

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摘要

《生药学研究》，2023,15,4806 -812. doi:10.5530/pres.15.4.085出版日期:2023年10月类型:原创文章作者:Mohammad Sharique, Hariprasad M.G, Moqbel Ali Moqbel Redhwan, Ashish Jain, Shambhavi S, Mamatha A, and Niranjana作者:Mohammad Sharique1, Hariprasad M.G1,2，*， Moqbel Ali Moqbel redhwan1,2, Ashish Jain1, Shambhavi S1, Mamatha A3, niranjan1印度卡纳塔克邦班加罗尔科勒药学院药理学系。2克尔药学院基础科学研究中心(校外)，印度卡纳塔克邦班加罗尔;3克尔药学院生药学教研室，印度卡纳塔克邦班加罗尔;4Pentacare Ayur Pharma, maleshwaram, Bengaluru，卡纳塔克邦，印度。摘要/ Abstract摘要:背景:抗结核药物(ATDs)在治疗结核病的同时具有肝毒性，可导致肝损伤和并发症。铜钙，一种传统的阿育吠陀制剂，已经显示出潜在的肝保护特性。目的:探讨铜钙对atd所致肝毒性的潜在保护作用，并观察其对大鼠肝功能指标和组织病理学变化的影响。材料与方法:雄性Wistar大鼠30只，随机分为5组(每组6只):对照组、ATD、铜钙、ATD+铜钙、水飞蓟素(标准保肝剂)。异烟肼、利福平和吡嗪酰胺联合给药25 d，观察ATD组、ATD+铜钙组和水飞蓟素组的肝毒性。各组分别口服6.17 mg/kg、12.33 mg/kg和300 mg/kg b.w的铜钙和水飞蓟素。在研究结束时测量肝功能指标，包括血清转氨酶和丙氨酸转氨酶(ALT)。肝脏组织病理检查也进行了。结果:通过血清SGPT、SGOT、ALT和ALP水平升高和肝组织病理改变，atg诱导的肝毒性明显。与ATD组相比，铜钙联合给药可显著降低SGPT、SGOT、ALT和ALP (p<0.05)，改善肝脏组织病理学改变。铜钙的肝保护作用与水飞蓟素相当。结论:铜钙对atd诱导的大鼠肝毒性具有显著的肝保护作用，这可以通过肝脏功能指标的正常化和组织病理学的改善来证明。这些发现表明，铜钙可能是一种有希望的辅助治疗，以减轻抗结核药物治疗相关的肝损伤。关键词:抗结核，抗氧化，铜钙，肝毒性，RatView:PDF (959.22 KB)

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Hepatoprotective Assessment of Copper Calx against Anti-Tubercular Drug-induced Hepatotoxicity in Rats

Pharmacognosy Research,2023,15,4,806-812.DOI:10.5530/pres.15.4.085Published:October 2023Type:Original ArticleAuthors:Mohammad Sharique, Hariprasad M.G, Moqbel Ali Moqbel Redhwan, Ashish Jain, Shambhavi S, Mamatha A, and Niranjana Author(s) affiliations:Mohammad Sharique1, Hariprasad M.G1,2,*, Moqbel Ali Moqbel Redhwan1,2, Ashish Jain1, Shambhavi S1, Mamatha A3, Niranjana4 1Department of Pharmacology, KLE College of Pharmacy, Bengaluru, Karnataka, INDIA. 2Basic Science Research Center (Off-Campus), KLE College of Pharmacy, Bengaluru, Karnataka, INDIA. 3Department of Pharmacognosy, KLE College of Pharmacy, Bengaluru, Karnataka, INDIA. 4Pentacare Ayur Pharma, Malleshwaram, Bengaluru, Karnataka, INDIA. Abstract:Background: Anti-Tubercular Drugs (ATDs), while effective in treating tuberculosis, are associated with hepatotoxicity, leading to liver damage and complications. Calx of Copper, a traditional Ayurvedic preparation, has shown potential hepatoprotective properties. Objectives: To investigate the potential hepatoprotective role of Calx of Copper in mitigating ATD-induced hepatotoxicity and to examine its impact on liver function markers and histopathological changes in rats. Materials and Methods: Thirty male Wistar rats were randomly divided into five groups (n=6 per group): control, ATD, Calx of Copper, ATD+Calx of Copper, and silymarin (used as a standard hepatoprotective agent). Hepatotoxicity was induced in the ATD, ATD+Calx of Copper, and silymarin groups by administering a combination of isoniazid, rifampicin, and pyrazinamide for 25 days. Calx of Copper and silymarin were orally administered at doses of 6.17 mg/kg and 12.33 mg/kg, and 300 mg/kg b.w, respectively, in their respective groups. Liver function markers, including serum transaminase and alanine Aminotransferase (ALT), were measured at the end of the study. A histopathological examination of liver tissues was also performed. Results: ATDinduced hepatotoxicity was evident through elevated serum SGPT, SGOT, ALT, and ALP levels and histopathological alterations in liver tissue. Co-administration of Calx of Copper significantly reduced SGPT, SGOT, ALT, and ALP (p<0.05) and improved liver histopathological changes compared to the ATD group. The hepatoprotective effect of Calx of Copper was comparable to that of silymarin. Conclusion: Copper calx demonstrated significant hepatoprotective activity against ATD-induced hepatotoxicity in rats, as evidenced by normalizing liver function markers and histopathological improvements. These findings suggest that Calx of Copper may be a promising adjuvant therapy for mitigating liver damage associated with anti-tubercular drug treatment. Keywords:Anti-Tubercular, Antioxidant, Copper Calx, Hepatotoxicity, RatView:PDF (959.22 KB)

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Pharmacognosy Research PHARMACOLOGY & PHARMACY-

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期刊介绍： Pharmacognosy Research [ISSN: Print -0976-4836, Online - 0974-8490] [http://www.phcogres.com], Quarterly a publication of Phcog.Net is published by Wolters Kluwer - Medknow Publications. It provides peer-reviewed original research articles from the field of Natural Products. The journal serves an international audience of scientists and researchers in a variety of research and academia by quickly disseminating research findings related to Medicinal Plants and Natural Products. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submissions of original contributions in all areas of pharmacognosy are welcome.