高强度间歇训练对超重和肥胖成人线粒体相关指标的影响:一项系统综述和荟萃分析

Spyridon Hadjispyrou, Petros C Dinas, Spyridon Marios Delitheos, Ioannis-Alexios Koumprentziotis, Costas Chryssanthopoulos, Anastassios Philippou
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引用次数: 0

摘要

背景:肥胖是一个发病率不断上升的重要健康问题,可引起低度全身炎症状态,并与多种慢性疾病有关。此外,肥胖已被证明会通过氧化应激和炎症导致线粒体功能障碍,最终影响能量代谢。然而,高强度间歇训练(HIIT)可以通过运动诱导的线粒体适应来提高线粒体效率。本系统综述和荟萃分析旨在研究HIIT对肥胖和超重成人线粒体相关指标的潜在影响。方法:检索PubMed、Scopus、Web of Science数据库。结果:纳入28项符合条件的研究,涉及530名受试者。研究发现,HIIT可显著改善超重和肥胖个体的柠檬酸合成酶(CS)、细胞色素C (COX-IV)、β-羟酰基辅酶a-脱氢酶(β-HAD)、复合物I-V和VO2max的活性,而PGC-1α和SIRT1无显著变化。有趣的是,亚组分析显示,CS、COX-IV、β-HAD和复合物I-V活性仅在健康亚组中有显著改善。结论:总体而言,HIIT可用于提高超重和肥胖个体的线粒体相关指标。然而,这种改善可能取决于健康状况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Effect of High-Intensity Interval Training on Mitochondrial-Associated Indices in Overweight and Obese Adults: A Systematic Review and Meta-Analysis
Background: Obesity is a significant health problem with an increasing incidence, causing a low-grade systemic inflammatory state and being implicated in various chronic diseases. Moreover, obesity has been shown to cause mitochondrial dysfunction through oxidative stress and inflammation, eventually affecting energy metabolism. However, high-intensity interval training (HIIT) can improve mitochondrial efficiency through exercise-induced mitochondrial adaptations. This systematic review and meta-analysis aims to examine the potential effects of HIIT on mitochondrial-associated indices in obese and overweight adults. Methods: PubMed, Scopus, and Web of Science databases were searched. Results: Twenty-eight eligible studies were included, involving 530 participants. HIIT was found to significantly improve the activity of citrate synthase (CS), cytochrome C (COX-IV), beta-hydroxyacyl CoA-dehydrogenase (β-HAD), Complexes I-V as well as VO2max in overweight and obese individuals, whereas no significant changes were shown in PGC-1α and SIRT1. Interestingly, subgroup analyses revealed that CS, COX-IV, β-HAD, and Complexes I-V activity exhibited a significant improvement only in the healthy subgroup. Conclusions: Overall, HIIT can be utilized to enhance mitochondrial-associated indices in overweight and obese individuals. However, this improvement may be health status dependent.
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