Tarık MECİT, Nadide NABIL KAMILOĞLU, Pelin ŞAHIN, Dinçer ERDAĞ, Oğuz MERHAN
{"title":"左旋肉碱和辅酶Q10对高血压氧化应激损伤的保护作用","authors":"Tarık MECİT, Nadide NABIL KAMILOĞLU, Pelin ŞAHIN, Dinçer ERDAĞ, Oğuz MERHAN","doi":"10.32707/ercivet.1259251","DOIUrl":null,"url":null,"abstract":"In this study, it was aimed to investigate the effects of L-carnitine and Co-enzyme Q10 administration together with ACE Inhibitor (ACE inh.) on oxidative stress parameters in liver, brain and kidney tissues in L-NAME hypertensive rats. At the study, divided all rats into eight groups, four groups with 14 days of experiment time and four groups with 28 days of experiment time. At the end of the experiment, the rats were euthanized and their liver, brain and kidney tissues were taken. Malondialdehyde (MDA), glutathione (GSH) and nitric oxide (NO) activities were measured in tissue supernatants. While NO and MDA levels increased in all tissues, a significant decrease was observed in GSH levels (P","PeriodicalId":11688,"journal":{"name":"Erciyes Üniversitesi Veteriner Fakültesi Dergisi","volume":"191 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Protective Effects of L-carnitine and Co-enzyme Q10 Against Oxidative Stress Damage in Hypertension\",\"authors\":\"Tarık MECİT, Nadide NABIL KAMILOĞLU, Pelin ŞAHIN, Dinçer ERDAĞ, Oğuz MERHAN\",\"doi\":\"10.32707/ercivet.1259251\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this study, it was aimed to investigate the effects of L-carnitine and Co-enzyme Q10 administration together with ACE Inhibitor (ACE inh.) on oxidative stress parameters in liver, brain and kidney tissues in L-NAME hypertensive rats. At the study, divided all rats into eight groups, four groups with 14 days of experiment time and four groups with 28 days of experiment time. At the end of the experiment, the rats were euthanized and their liver, brain and kidney tissues were taken. Malondialdehyde (MDA), glutathione (GSH) and nitric oxide (NO) activities were measured in tissue supernatants. While NO and MDA levels increased in all tissues, a significant decrease was observed in GSH levels (P\",\"PeriodicalId\":11688,\"journal\":{\"name\":\"Erciyes Üniversitesi Veteriner Fakültesi Dergisi\",\"volume\":\"191 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-03-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Erciyes Üniversitesi Veteriner Fakültesi Dergisi\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.32707/ercivet.1259251\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Erciyes Üniversitesi Veteriner Fakültesi Dergisi","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32707/ercivet.1259251","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Protective Effects of L-carnitine and Co-enzyme Q10 Against Oxidative Stress Damage in Hypertension
In this study, it was aimed to investigate the effects of L-carnitine and Co-enzyme Q10 administration together with ACE Inhibitor (ACE inh.) on oxidative stress parameters in liver, brain and kidney tissues in L-NAME hypertensive rats. At the study, divided all rats into eight groups, four groups with 14 days of experiment time and four groups with 28 days of experiment time. At the end of the experiment, the rats were euthanized and their liver, brain and kidney tissues were taken. Malondialdehyde (MDA), glutathione (GSH) and nitric oxide (NO) activities were measured in tissue supernatants. While NO and MDA levels increased in all tissues, a significant decrease was observed in GSH levels (P
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