一些具有潜在生物活性的吡啶-甲酰胺新衍生物的合成与表征

IF 2.4 3区 化学 Q2 CHEMISTRY, ORGANIC
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引用次数: 0

摘要

本研究报告采用简便的合成路线,获得了一些含有强效药效基团的新杂环体系,如吡唑、吡唑并[5,1-c]-1,2,4-三嗪、1,2,4-三嗪并[4,3-a]苯并咪唑,以及与吡啶-甲酰胺基团相连的吡啶基团。3-oxo-butanamides 1a,b 分别与肼酰卤化物、杂环重氮盐和丙二腈衍生物反应,生成了目标化合物。所有可能的光谱和元素分析都证实了新产品的结构。抗菌评估结果表明,其中一种产品对肺炎双球菌和金黄色葡萄球菌均有中度活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synthesis and Characterization of Some New Pyridine-Carboxamide Derivatives of Potential Biological Activities
A facile synthetic routes to access some new heterocyclic systems containing potent pharmacophoric groups such as pyrazole, pyrazolo[5,1-c]-1,2,4-triazine, 1,2,4-triazino[4,3-a]benzimidazole, and pyridine moieties linked to pyridine-carboxamide moiety are reported. Construction of the target compounds was achieved via reaction of 3-oxo-butanamides 1a,b with hydrazonoyl halides, heterocyclic diazonium salts, and malononitrile derivatives, respectively. The structures of the new products were confirmed by all possible spectral and elemental analyses. The antibacterial assessment showed that one product was moderately active against both K. pneumonia and S. aureus.
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来源期刊
Polycyclic Aromatic Compounds
Polycyclic Aromatic Compounds 化学-有机化学
CiteScore
3.70
自引率
20.80%
发文量
412
审稿时长
3 months
期刊介绍: The purpose of Polycyclic Aromatic Compounds is to provide an international and interdisciplinary forum for all aspects of research related to polycyclic aromatic compounds (PAC). Topics range from fundamental research in chemistry (including synthetic and theoretical chemistry) and physics (including astrophysics), as well as thermodynamics, spectroscopy, analytical methods, and biology to applied studies in environmental science, biochemistry, toxicology, and industry. Polycyclic Aromatic Compounds has an outstanding Editorial Board and offers a rapid and efficient peer review process, as well as a flexible open access policy.
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