{"title":"pd-l1在非肌肉侵袭性和肌肉侵袭性尿路上皮膀胱癌中的定量免疫荧光评价","authors":"T.A. Bogush, K.S. Spiridonova, E.A. Bogush, A.N. Grishanina, A.M. Scherbakov, M.I. Volkova, Z.M. Safarov, V.B. Matveev, V.S. Kosorukov","doi":"10.55959/msu0579-9384-2-2023-64-6-559-567","DOIUrl":null,"url":null,"abstract":"The expression of PD-L1 protein was quanti ed in 56 samples of urothelial bladder cancer (BC). PD-L1 expression was detected in all BC samples, while in non-muscle-invasive bladder cancer (NMIBC) the median value is 1,5 times higher than in muscle-invasive bladder cancer (MIBC) (p = 0,001). High PD-L1 expression level (≥30%) was observed in 20% of MIBC samples and among NMIBC tumors - in 68% of cases, that is 3,4 times more often (p = 0,0004). The last fact justi es the prospect of starting therapy with immune checkpoint inhibitors already at the onset of the disease - at NMIBC.","PeriodicalId":23660,"journal":{"name":"Vestnik Moskovskogo Universiteta Seriya 2 Khimiya","volume":"356 7","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"QUANTITATIVE IMMUNOFLUORESCENCE EVALUATION OF PD-L1 EXPRESSION IN NON-MUSCLE-INVASIVE AND MUSCLE-INVASIVE UROTHELIAL BLADDER CANCER\",\"authors\":\"T.A. Bogush, K.S. Spiridonova, E.A. Bogush, A.N. Grishanina, A.M. Scherbakov, M.I. Volkova, Z.M. Safarov, V.B. Matveev, V.S. Kosorukov\",\"doi\":\"10.55959/msu0579-9384-2-2023-64-6-559-567\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The expression of PD-L1 protein was quanti ed in 56 samples of urothelial bladder cancer (BC). PD-L1 expression was detected in all BC samples, while in non-muscle-invasive bladder cancer (NMIBC) the median value is 1,5 times higher than in muscle-invasive bladder cancer (MIBC) (p = 0,001). High PD-L1 expression level (≥30%) was observed in 20% of MIBC samples and among NMIBC tumors - in 68% of cases, that is 3,4 times more often (p = 0,0004). The last fact justi es the prospect of starting therapy with immune checkpoint inhibitors already at the onset of the disease - at NMIBC.\",\"PeriodicalId\":23660,\"journal\":{\"name\":\"Vestnik Moskovskogo Universiteta Seriya 2 Khimiya\",\"volume\":\"356 7\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-11-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Vestnik Moskovskogo Universiteta Seriya 2 Khimiya\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.55959/msu0579-9384-2-2023-64-6-559-567\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vestnik Moskovskogo Universiteta Seriya 2 Khimiya","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.55959/msu0579-9384-2-2023-64-6-559-567","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
QUANTITATIVE IMMUNOFLUORESCENCE EVALUATION OF PD-L1 EXPRESSION IN NON-MUSCLE-INVASIVE AND MUSCLE-INVASIVE UROTHELIAL BLADDER CANCER
The expression of PD-L1 protein was quanti ed in 56 samples of urothelial bladder cancer (BC). PD-L1 expression was detected in all BC samples, while in non-muscle-invasive bladder cancer (NMIBC) the median value is 1,5 times higher than in muscle-invasive bladder cancer (MIBC) (p = 0,001). High PD-L1 expression level (≥30%) was observed in 20% of MIBC samples and among NMIBC tumors - in 68% of cases, that is 3,4 times more often (p = 0,0004). The last fact justi es the prospect of starting therapy with immune checkpoint inhibitors already at the onset of the disease - at NMIBC.
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