研制新型小体积氧合器,建立小动物离体肺灌注水动力试验台

IF 0.2 Q4 TRANSPLANTATION
O. Yu. Esipova, V. K. Bogdanov, A. S. Esipov, A. P. Kuleshov, A. S. Buchnev, E. A. Volkova, A. A. Drobyshev, N. V. Grudinin
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引用次数: 0

摘要

小动物模型广泛应用于基础研究。然而,实验水动力测试平台,包括体外电路,往往有限制与设备的尺寸和填充体积。因此,我们旨在开发和验证用于小动物肺离体灌注的微型氧合器和小体积流体动力系统。设计并制造了一系列小容量膜式氧合器(n = 10),该氧合器由90-100根排列的微孔聚丙烯中空纤维组成,置于两端密封的护套内,以隔离灌注溶液。这种设计使气体流经中空纤维,并在纤维周围弥漫循环。设计并组装了一个小体积水动力试验台,用于离体体外肺灌注,并评估氧合器的性能特征:5-70 ml/min流量范围内的气体和灌注流量、灌注压力和温度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Development of a new low-volume oxygenator and creation of a hydrodynamic test bench for ex vivo lung perfusion in small animals
Small animal models are widely used in basic research. However, experimental hydrodynamic test benches, which include extracorporeal circuits, often have limitations associated with the size and filling volume of equipment. Thus, we aimed at developing and validating a miniature oxygenator as well as a low-volume hydrodynamic system for ex vivo perfusion of small animal lungs. A series of low-volume membrane oxygenators (n = 10) with 90–100 aligned microporous polypropylene hollow fibers, placed inside a sheath that is sealed at both ends to isolate the perfusing solution, was designed and manufactured. This design makes gas to flow through the hollow fibers and perfusate to circulate around the fibers. A low-volume hydrodynamic test bench was designed and assembled for isolated ex vivo lung perfusion and for evaluation of the performance characteristics of the oxygenators: gas and perfusate flow, perfusion pressure and temperature at 5–70 ml/min flow range.
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来源期刊
CiteScore
0.70
自引率
50.00%
发文量
46
审稿时长
12 weeks
期刊介绍: Organ transplantation is one of the most challenging and complex areas of modern medicine, based on a rapid development of innovative technologies in surgery, anesthesiology and intensive care, cardiovascular surgery, immunology, molecular biology, biotechnology, and natural sciences. Regenerative medicine and the development of artificial and bioartificial organs and systems are the key issues for further progress in transplantation. Cardiology, nephrology, hepatology, endocrinology, and many other medical areas constitute the basis of clinical transplantation. Organization and coordination of organ donation present a serious challenge on a state level requiring cooperation and active work of various health authorities. The development of clinical transplantation in Russia has led to the formation of a wide network of transplant centers. Hundreds of hearts, kidneys, livers, lungs, and pancreases transplantations perform annually. Improvement of transplant availability for patients and an increased number of professionals involved in the transplantation process are the contemporary realities in the Russian Federation. Thus, the journal aims to serve as a forum for an exchange of research information, clinical expertise, current trends and the recent developments in the field of transplantation and organ donation.
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