{"title":"邻苯二甲酸二异壬基和邻苯二甲酸二异癸基的环境发生、人体暴露和内分泌干扰:系统综述","authors":"Kyung Joo Lee, Kyungho Choi","doi":"10.1080/10643389.2023.2261815","DOIUrl":null,"url":null,"abstract":"AbstractDi-iso-nonyl phthalate (DINP) and di-iso-decyl phthalate (DIDP) have been employed increasingly as plasticizers to replace di-(2-ethylhexyl) phthalate (DEHP), a hormonal disruptor. Through this systematic review, we reviewed their (1) contamination levels in the environmental media, foods, and consumer products, (2) human exposure levels in national biomonitoring studies, and (3) associations with human sex and thyroid hormone disruption. PubMed, Scopus, and Web of Science were searched and eligible studies were identified. DINP and DIDP were found at higher concentrations in indoor environments, especially with high human activity and PVC use. In foods, contamination levels vary by production methods and tend to be higher in fatty foods. In children’s products, both plasticizers were more highly detected in samples measured before 2010. National biomonitoring data from several countries demonstrated that urinary levels of DINP and DIDP metabolites were relatively lower than those of DEHP. However, exposure to DINP has been associated with anti-androgenic potential in male offspring and adults and decreased thyroid hormones in mother–child pairs. In conclusion, existing literatures demonstrated widespread occurrence of DINP and DIDP in the indoor environment, diet, and children’s products, and in the human populations worldwide. At the current levels of exposure, DINP exhibited endocrine disruption potentials similar to those of DEHP, especially among males and pregnant women. Knowledge gaps in DIDP exposure among the human population were identified and should be considered for future studies.Keywords: Plasticizersphthalate acid esters (PAEs)exposurebiomonitoringendocrinesystematicreviewHANDLING EDITORS: Eakalak Khan and Lena Q. Ma Disclosure statementNo potential conflict of interest was reported by the authors.The conclusions, findings, and opinions expressed in this scientific paper reflect only the view of the authors and are not the official position of Health Canada.Additional informationFundingThis research was supported by National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2020R1A2C3011269).","PeriodicalId":10823,"journal":{"name":"Critical Reviews in Environmental Science and Technology","volume":"299 1","pages":"0"},"PeriodicalIF":11.4000,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Environmental occurrence, human exposure, and endocrine disruption of di-iso-nonyl phthalate and di-iso-decyl phthalate: A systematic review\",\"authors\":\"Kyung Joo Lee, Kyungho Choi\",\"doi\":\"10.1080/10643389.2023.2261815\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"AbstractDi-iso-nonyl phthalate (DINP) and di-iso-decyl phthalate (DIDP) have been employed increasingly as plasticizers to replace di-(2-ethylhexyl) phthalate (DEHP), a hormonal disruptor. Through this systematic review, we reviewed their (1) contamination levels in the environmental media, foods, and consumer products, (2) human exposure levels in national biomonitoring studies, and (3) associations with human sex and thyroid hormone disruption. PubMed, Scopus, and Web of Science were searched and eligible studies were identified. DINP and DIDP were found at higher concentrations in indoor environments, especially with high human activity and PVC use. In foods, contamination levels vary by production methods and tend to be higher in fatty foods. In children’s products, both plasticizers were more highly detected in samples measured before 2010. National biomonitoring data from several countries demonstrated that urinary levels of DINP and DIDP metabolites were relatively lower than those of DEHP. However, exposure to DINP has been associated with anti-androgenic potential in male offspring and adults and decreased thyroid hormones in mother–child pairs. In conclusion, existing literatures demonstrated widespread occurrence of DINP and DIDP in the indoor environment, diet, and children’s products, and in the human populations worldwide. At the current levels of exposure, DINP exhibited endocrine disruption potentials similar to those of DEHP, especially among males and pregnant women. Knowledge gaps in DIDP exposure among the human population were identified and should be considered for future studies.Keywords: Plasticizersphthalate acid esters (PAEs)exposurebiomonitoringendocrinesystematicreviewHANDLING EDITORS: Eakalak Khan and Lena Q. Ma Disclosure statementNo potential conflict of interest was reported by the authors.The conclusions, findings, and opinions expressed in this scientific paper reflect only the view of the authors and are not the official position of Health Canada.Additional informationFundingThis research was supported by National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2020R1A2C3011269).\",\"PeriodicalId\":10823,\"journal\":{\"name\":\"Critical Reviews in Environmental Science and Technology\",\"volume\":\"299 1\",\"pages\":\"0\"},\"PeriodicalIF\":11.4000,\"publicationDate\":\"2023-10-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Critical Reviews in Environmental Science and Technology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/10643389.2023.2261815\",\"RegionNum\":1,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Critical Reviews in Environmental Science and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/10643389.2023.2261815","RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
引用次数: 0
摘要
摘要邻苯二甲酸二异壬基酯(DINP)和邻苯二甲酸二异癸基酯(DIDP)越来越多地被用作增塑剂,以取代激素干扰物邻苯二甲酸二(2-乙基己基)酯(DEHP)。通过这篇系统综述,我们回顾了它们(1)在环境介质、食品和消费品中的污染水平,(2)在国家生物监测研究中的人类暴露水平,以及(3)与人类性和甲状腺激素紊乱的关系。检索PubMed、Scopus和Web of Science并确定符合条件的研究。DINP和DIDP在室内环境中浓度较高,特别是在人类活动频繁和聚氯乙烯使用的环境中。在食品中,污染程度因生产方法而异,脂肪食品的污染程度往往更高。在儿童产品中,2010年以前检测到的这两种增塑剂的含量更高。来自几个国家的国家生物监测数据表明,尿中DINP和DIDP代谢物的水平相对低于DEHP。然而,暴露于DINP与雄性后代和成人的抗雄激素潜能以及母子对甲状腺激素的降低有关。综上所述,现有文献表明,DINP和DIDP在室内环境、饮食、儿童产品以及世界范围内的人群中广泛存在。在目前的暴露水平下,DINP表现出与DEHP相似的内分泌干扰潜力,特别是在男性和孕妇中。确定了人群中DIDP暴露方面的知识差距,并应在今后的研究中加以考虑。关键词:增塑剂邻苯二甲酸酯(PAEs)暴露生物监测内分泌系统评价编辑:Eakalak Khan和Lena Q. Ma披露声明作者未报告潜在利益冲突。本科学论文中的结论、发现和观点仅反映作者的观点,不代表加拿大卫生部的官方立场。本研究由韩国政府(MSIT)资助的韩国国家研究基金会(NRF)资助(No. 2020R1A2C3011269)。
Environmental occurrence, human exposure, and endocrine disruption of di-iso-nonyl phthalate and di-iso-decyl phthalate: A systematic review
AbstractDi-iso-nonyl phthalate (DINP) and di-iso-decyl phthalate (DIDP) have been employed increasingly as plasticizers to replace di-(2-ethylhexyl) phthalate (DEHP), a hormonal disruptor. Through this systematic review, we reviewed their (1) contamination levels in the environmental media, foods, and consumer products, (2) human exposure levels in national biomonitoring studies, and (3) associations with human sex and thyroid hormone disruption. PubMed, Scopus, and Web of Science were searched and eligible studies were identified. DINP and DIDP were found at higher concentrations in indoor environments, especially with high human activity and PVC use. In foods, contamination levels vary by production methods and tend to be higher in fatty foods. In children’s products, both plasticizers were more highly detected in samples measured before 2010. National biomonitoring data from several countries demonstrated that urinary levels of DINP and DIDP metabolites were relatively lower than those of DEHP. However, exposure to DINP has been associated with anti-androgenic potential in male offspring and adults and decreased thyroid hormones in mother–child pairs. In conclusion, existing literatures demonstrated widespread occurrence of DINP and DIDP in the indoor environment, diet, and children’s products, and in the human populations worldwide. At the current levels of exposure, DINP exhibited endocrine disruption potentials similar to those of DEHP, especially among males and pregnant women. Knowledge gaps in DIDP exposure among the human population were identified and should be considered for future studies.Keywords: Plasticizersphthalate acid esters (PAEs)exposurebiomonitoringendocrinesystematicreviewHANDLING EDITORS: Eakalak Khan and Lena Q. Ma Disclosure statementNo potential conflict of interest was reported by the authors.The conclusions, findings, and opinions expressed in this scientific paper reflect only the view of the authors and are not the official position of Health Canada.Additional informationFundingThis research was supported by National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2020R1A2C3011269).
期刊介绍:
Two of the most pressing global challenges of our era involve understanding and addressing the multitude of environmental problems we face. In order to tackle them effectively, it is essential to devise logical strategies and methods for their control. Critical Reviews in Environmental Science and Technology serves as a valuable international platform for the comprehensive assessment of current knowledge across a wide range of environmental science topics.
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