多神经病变严重程度对2型糖尿病患者神经传导及疼痛综合征的影响

A.Ya. Sabovchyk, M.M. Oros
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摘要

背景。本文探讨2型糖尿病患者神经传导指标与多神经病变严重程度的关系。研究多发性神经病严重程度对神经传导的影响,以及胰岛素治疗对这些指标的影响。目的:探讨2型糖尿病患者多神经病变严重程度及是否需要追加胰岛素给药对神经传导指标及疼痛综合征发生的影响。材料和方法。80名2型糖尿病患者接受了检查,其中49名男性,31名女性。所有患者均接受了一般临床和生化实验室检查,以评估造血系统、肝、肾、脂肪和碳水化合物代谢。通过c肽水平评估是否需要胰岛素治疗。为了验证糖尿病多发性神经病变的诊断,我们评估了主诉、临床和仪器检查资料。判断多神经炎病变时考虑神经传导的主要指标,即:腓肠运动神经传导速度、腓肠神经感觉神经动作电位、腓肠神经感觉神经传导速度。结果。神经传导速度与多发性神经病变严重程度有一定的相关性,严重多发性神经病变组的运动神经传导速度最低。感觉指标(感觉神经动作电位和感觉神经传导速度)水平与多神经病变严重程度之间也存在相关性,神经传导速度随严重程度的增加而降低。已发现多发性神经病的严重程度对疼痛或无痛形式的影响。在严重的多发性神经病患者中,疼痛形式更常见。没有发现胰岛素治疗的需要与多神经病变的疼痛或无痛形式之间的关系。结论。神经传导指标取决于多发性神经病的严重程度。疼痛综合征的存在和严重程度直接取决于多发性神经病变的严重程度。需要额外的胰岛素给药会影响感觉指标,但对多神经病变的疼痛形式的发展没有影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of polyneuropathy severity on nerve conduction and pain syndrome in patients with type 2 diabetes
Background. The article examines the relationship between nerve conduction indicators and polyneuropathy severity in patients with type 2 diabetes. The influence of polyneuropathy severity on nerve conduction was studied, as well as the effect of insulin therapy on these indicators. Objective: to determine the influence of polyneuropathy severity and the need for additional insulin administration in patients with type 2 diabetes on nerve conduction indicators and the development of pain syndrome. Materials and methods. Eighty patients with type 2 diabetes were examined, 49 men and 31 women. All of them underwent general clinical and biochemical laboratory tests to evaluate the hematopoietic system, li-ver, kidneys, fat and carbohydrate metabolism. The need for insulin therapy was assessed by the C-peptide level. To verify the diagnosis of diabetic polyneuropathy, complaints, clinical and instrumental examination data were evaluated. The main indicators of nerve conduction were taken into account when determining polyneuritis disorders, namely: рeroneal motor nerve conduction velocity, sensory nerve action potential of the sural nerve, sensory nerve conduction velocity of the sural nerve. Results. A dependence of nerve conduction on polyneuropathy severity was revealed, рeroneal motor nerve conduction velocity was the lowest in the group with severe polyneuropathy. A correlation was also found between the levels of sensory indicators (sensory nerve action potential and sensory nerve conduction velocity) and polyneuropathy severity, nerve conduction velocity decreases with an increase in the latter. The influence of polyneuropathy severity on the painful or painless form has been found. Among patients with severe polyneuropathy, the painful form was observed more often. No relationship was found between the need for insulin therapy and the painful or painless form of polyneuropathy. Conclusions. Indicators of nerve conduction depend on polyneuropathy severity. The presence and severity of pain syndrome directly depends on polyneuropathy severity. The need for additional insulin administration affects sensory indicators but has no effect on the development of the painful form of polyneuropathy.
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