白细胞在ph阴性骨髓增殖性肿瘤中性粒细胞胞外陷阱形成和血栓形成中的作用:文献综述

Q4 Medicine

Klinicheskaya Onkogematologiya/Clinical Oncohematology Pub Date : 2023-03-03 DOI:10.21320/2500-2139-2023-16-3-263-267

Болдукыз Толгонбаевна Джумабаева

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引用次数: 0

摘要

慢性ph阴性骨髓增生性肿瘤(mpn)患者的血栓性并发症常导致死亡。尽管有大量的研究，但MPN患者血栓形成的发病机制仍不清楚。其机理复杂，受多种因素的影响。血栓形成的一个基本阶段的特点是细胞机制的激活和中性粒细胞胞外陷阱(NETs)的形成。net由DNA链、组蛋白、颗粒蛋白组成，随着病原体的破坏，为血小板和凝血机制的激活提供了理想的基质。

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The Role of Leukocytes in the Formation of Neutrophil Extracellular Traps and Thrombosis in Ph-Negative Myeloproliferative Neoplasms: A Literature Review

Thrombotic complications often cause death in patients with chronic Ph-negative myeloproliferative neoplasms (MPNs). In spite of numerous studies, the pathogenesis of thrombus formation in MPN patients remains unclear. Its mechanism is complex and is determined by many factors. One of the essential phases in thrombogenesis is characterized by the activation of cell mechanisms and formation of neutrophil extracellular traps (NETs). NETs consist of DNA strands, histones, granular proteins and along with pathogen destruction provide an ideal matrix for platelet and clotting mechanism activation.

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来源期刊

Klinicheskaya Onkogematologiya/Clinical Oncohematology Medicine-Oncology

CiteScore

0.80

自引率

0.00%

发文量

审稿时长

12 weeks