肾氧饱和度在感染性休克患儿中的作用

IF 1.2 Q3 EMERGENCY MEDICINE
Neurinda Permata Kusumastuti, Teddy Ontoseno, Anang Endaryanto
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引用次数: 0

摘要

摘要简介:感染性休克是儿童中最严重的败血症,发病率和死亡率都很高。在感染性休克患者中,微循环灌注受损与器官衰竭的严重程度和死亡的可能性有关。因为近红外光谱(NIRS)可以直接和无创地评估微循环状态和外周组织氧合,提供实时结果,并且可以在患者床边进行。本研究旨在确定近红外光谱(NIRS)测定的肾氧饱和度(rrso2)在儿童感染性休克中的预后价值。方法:这项前瞻性观察性研究纳入了2020年8月至2021年1月期间在儿科重症监护病房接受治疗的1个月至18岁感染性休克患儿。根据脓毒症和脓毒症休克第三次国际共识定义,采用近红外光谱(NIRS)测量诊断为脓毒症休克患者的rRSO2。基线rrso2值(%)形成受试者工作特征曲线,用于计算最佳临界值、敏感性、特异性和优势比(OR)。结果:我们纳入了24例患者,13例非幸存者和11例幸存者,他们的平均基线rRSO2值分别为67.27±12.95和48.69±16.17 (P = 0.006)。基线rRSO2的最佳截断值为60.5%,敏感性为76.9%,特异性为81.8%,曲线下面积为0.804(95%可信区间[CI]: 59.2% ~ 98.1%, P = 0.012;或= 15;95 ci: 2.04-111.74)。结论:通过近红外光谱测量,rrso2值可以很好地预测感染性休克儿童的死亡率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Roles of Renal Oxygen Saturation in Septic Shock Children
Abstract Introduction: Septic shock, the most severe form of sepsis, has high morbidity and mortality rates among children. In patients with septic shock, impaired microcirculatory perfusion is associated with the severity of organ failure and the likelihood of death. Because near-infrared spectroscopy (NIRS) can assess microcirculation status and peripheral tissue oxygenation directly and noninvasively, provides real-time results, and can be performed at the patient’s bedside. This study aimed to determine the prognostic value of renal oxygen saturation (rRSO 2 ) measured by NIRS in septic shock among children. Methods: This prospective observational study enrolled children aged 1 month to 18 years with septic shock who were treated in a pediatric intensive care unit from August 2020 to January 2021. NIRS was used to measure rRSO2 in patients diagnosed with septic shock according to the Third International Consensus Definition of Sepsis and Septic Shock. The baseline rRSO 2 value (%) formed a receiver operating characteristic curve and was used to calculate the optimal cutoff value, sensitivity, specificity, and odds ratio (OR). Results: We enrolled 24 patients, 13 nonsurvivors and 11 survivors, whose mean baseline rRSO2 values were 67.27 ± 12.95 versus 48.69 ± 16.17, respectively ( P = 0.006). The optimal cutoff value for baseline rRSO2 was <60.5%, with a sensitivity of 76.9%, a specificity of 81.8%, and an area under curve 0.804 (95% confidence interval [CI]: 59.2%–98.1%, P = 0.012; OR = 15; 95 CI: 2.04–111.74). Conclusion: Measured by NIRS, rRSO 2 values are a good predictor of mortality among children with septic shock.
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来源期刊
CiteScore
2.90
自引率
7.10%
发文量
52
审稿时长
39 weeks
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