Ag2O/GO/TiO2复合纳米结构1,4-二氢吡啶衍生物的合成及细胞毒活性评价

IF 0.4 4区 化学 Q4 CHEMISTRY, MULTIDISCIPLINARY
Fatemeh Samandi ZADEH, Mohammad Kazem MOHAMMADI, Ayeh RAYATZADEH, Neda HASANZADEH
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引用次数: 0

摘要

建立了Ag2O/GO/TiO2复合纳米结构,作为Hantzsch反应一锅法合成二氢吡啶衍生物的非均相催化剂。该合成方法主要在Ag2O/GO/TiO2纳米复合材料作为非均相固体催化剂存在的情况下进行。该纳米复合材料在90°C无溶剂条件下催化Hantzsch反应,产率高达87-95%。成功地应用了多种结构多样的醛类化合物,得到了产率高、无副产物的相应产物。与其它方法相比,具有收率高、反应时间短、操作简单等优点。用MTT法测定了部分合成化合物对HeLa、LS180和Raji三种人癌细胞的细胞毒活性。一半的测试化合物在Raji细胞中显示出良好的细胞毒性。二乙基4-(2,4-二氯苯基)-1,4-二氢-2,6-二甲基吡啶-3,5-二羧酸酯(3 i)是所研究的1,4二氢吡啶衍生物中最有效的分子。吸电子基团和含更多杂原子的杂环似乎是在Raji细胞系中提供更高细胞毒活性的必要因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synthesis and cytotoxic activity evaluation of 1,4-dihydropyridine derivatives using Ag2O/GO/TiO2 composite nanostructure
Ag2O/GO/TiO2 composite nanostructure was established as a heterogeneous catalyst for the one pot synthesis of dihydropyridine derivatives via Hantzsch reaction. The synthetic method was mainly used in the presence of Ag2O/GO/TiO2 nano composite as a heterogeneous solid catalyst. This nano composite catalyzed Hantzsch reaction afforded good yields (87–95%) in solvent free condition at 90 °C. A broad range of structurally diverse aldehydes were applied successfully, and corresponding products were obtained in high yields without any byproduct. Compared with other methods, satisfactory results are obtained with high yields, short reaction times, and simplicity in the experimental procedure. Cytotoxic activities for some of the synthesized compounds were evaluated by MTT assay in three human cancer cell lines (HeLa, LS180 and Raji). Half of the tested compounds showed good cytotoxicity in Raji cells. Diethyl 4-(2,4-dichlorophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate (3 i) was found to be the most potent molecule among the studied 1, 4 dihydropyridines derivatives. Electron withdrawing groups along with heterocyclic rings bearing more hetero atoms seemed to be necessary factors in providing higher cytotoxic activities in Raji cell lines.
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来源期刊
Revue Roumaine De Chimie
Revue Roumaine De Chimie 化学-化学综合
CiteScore
0.80
自引率
20.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: The journal Revue Roumaine de Chimie (Roumanian Journal of Chemistry) was founded in 1956 under the name Revue de Chimie. Acad. R. P. R. from 1964, the title was modified in Revue Roumaine de Chimie (preserving the numbering of the volumes started in 1956). In 1997, the English translation of the title – Roumanian Journal of Chemistry – was also included on each issue.
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