上转换纳米颗粒在生物医学领域的应用

MATEC Web of Conferences Pub Date : 2023-01-01 DOI:10.1051/matecconf/202338603005

Zhihan Cai

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引用次数: 0

摘要

上转换纳米粒子(UCNPs)是目前最受关注的检测技术之一。UCNPs是一种基于稀土离子反斯托克斯反应的新型发光材料。它们的优点是在发光材料中掺杂稀土离子，具有高信噪比、强荧光强度、约100毫秒的长荧光寿命、良好的生物相容性和低毒性。发射带窄，穿透能力强，对基体和界面损伤小。如今，基于UCNPs和跨学科融合的检测技术为生物分析、生物工程、材料等领域的新型检测方法和仪器的发展奠定了坚实的基础，并在各个领域得到了广泛的应用。为此，本研究将解释UCNPs的基本原理和镧系元素的影响。本研究还讨论了UCNPs在磁共振成像(MRI)、光动力治疗(PDT)、生物标志物和免疫分析等生物医学领域的实际应用，并对未来的研究进行了展望。

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Application of Upconversion Nanoparticles in Biomedical Field

Upconversion nanoparticles (UCNPs) are currently one of the most concerned detection technologies. UCNPs are a new kind of luminescent material based on the anti-Stokes reaction of rare-earth ions. Their advantages lie in the doping of rare-earth ions in the luminescent material, which has a high signal to noise ratio and strong fluorescence intensity, has a long fluorescence lifetime of approximately 100 milliseconds, good bio-compatibility and low toxicity. The emission band is narrow and has high penetration power and there is less damage to the matrix and interface. Nowadays, detection technologies based on UCNPs and interdisciplinary integration have laid a solid foundation for the development of new detection methods and instruments in fields such as bioanalysis, bioengineering, and materials, and have been widely applied in various fields. To this end, this research will explain the basic principle of UCNPs and the influence of lanthanide factors. This research also discussed the practical applications of UCNPs in magnetic resonance imaging (MRI), photodynamic therapy (PDT), biomarkers, and immunoassays in biomedical field, and looked forward to future research on UCNPs.

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来源期刊

MATEC Web of Conferences

自引率

0.00%

发文量

342

审稿时长

6 weeks

期刊介绍： MATEC Web of Conferences is an Open Access publication series dedicated to archiving conference proceedings dealing with all fundamental and applied research aspects related to Materials science, Engineering and Chemistry. All engineering disciplines are covered by the aims and scope of the journal: civil, naval, mechanical, chemical, and electrical engineering as well as nanotechnology and metrology. The journal concerns also all materials in regard to their physical-chemical characterization, implementation, resistance in their environment… Other subdisciples of chemistry, such as analytical chemistry, petrochemistry, organic chemistry…, and even pharmacology, are also welcome. MATEC Web of Conferences offers a wide range of services from the organization of the submission of conference proceedings to the worldwide dissemination of the conference papers. It provides an efficient archiving solution, ensuring maximum exposure and wide indexing of scientific conference proceedings. Proceedings are published under the scientific responsibility of the conference editors.