阿拉伯茶(catha edulis)废料纳米纤化纤维素气凝胶:制备和表征

IF 1.3 4区农林科学 Q2 MATERIALS SCIENCE, PAPER & WOOD

Cellulose Chemistry and Technology Pub Date : 2023-09-29 DOI:10.35812/cellulosechemtechnol.2023.57.67

JEMAL DILEBO, TESFAYE GABRIEL, KEBEDE WONDU

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引用次数: 0

摘要

采用无氯法从阿拉伯茶废(KW)中提取纤维素纤维，对KW纳米纤化纤维素进行冷冻干燥制备气凝胶，并在气凝胶中负载模型药物双氯芬酸钠。采用不同的仪器技术对载药气凝胶(LA)、未载药气凝胶(ULA)、提取纤维素(Cel)和KW进行了表征。纤维素纤维纳米纤颤作用4 h，得到83.06%的纳米纤维。ULA结晶度指数低于Cel (53.89% vs 65.22%)，但热稳定性高于LA和Cel。每100 mg纳米纤维的载药量为11.7 mg纯药物。在6小时内，LA的体外药物释放量小于负载药物的三分之一(即31.4%)。研究结果表明，纳米纤化纤维素气凝胶可以由KW制备，并可能在药物递送等领域具有潜在的应用前景。

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NANOFIBRILLATED CELLULOSE AEROGEL FROM KHAT (CATHA EDULIS) WASTE: FABRICATION AND CHARACTERIZATIONS

Cellulose fiber was extracted from khat waste (KW) using the chlorine free method and an aerogel was prepared by freeze drying of nanofibrillated cellulose of KW. The aerogel was loaded with a model drug, diclofenac sodium. The drug loaded aerogel (LA), drug unloaded aerogel (ULA), as-extracted cellulose (Cel) and KW were characterized using different instrumental techniques. Nanofibrillation of the cellulose fiber for 4 h gave 83.06% nanofiber. ULA had lower crystallinity index, as compared to Cel (53.89% vs 65.22%), but had higher thermal stability than LA and Cel. The drug loading capacity of the aerogel was 11.7 mg of pure drug per 100 mg of the nanofiber. The in vitro drug release from LA was less than one-third of the loaded drug (i.e., 31.4%) within 6 h. The findings highlight that nanofibrillated cellulose aerogel can be prepared from KW and may have potential applications in areas such as drug delivery.

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来源期刊

Cellulose Chemistry and Technology 工程技术-材料科学：纸与木材

CiteScore

2.30

自引率

23.10%

发文量

审稿时长

7.3 months

期刊介绍： Cellulose Chemistry and Technology covers the study and exploitation of the industrial applications of carbohydrate polymers in areas such as food, textiles, paper, wood, adhesives, pharmaceuticals, oil field applications and industrial chemistry. Topics include: • studies of structure and properties • biological and industrial development • analytical methods • chemical and microbiological modifications • interactions with other materials