Musk ketone solubility in binary systems ethyl acetate with methanol, ethanol, and isopropanol: preferential solvation according to the inverse Kirkwood–Buff integrals method

ABSTRACTThree co-solvent mixtures {methanol (1) + ethyl acetate (2), ethanol (1) + ethyl acetate (2), and isopropanol (1) + ethyl acetate} were used to calculate the preferred solvation parameters (δx1,3) of musk ketone (MK) (2). In all co-solvent mixes, δx1,3 values vary non-linearly with the percentage of co-solvent (1). According to the study, δx1,3values are negative in mixes rich in alcohol but positive in those high in ethyl acetate. The mixtures {methanol (1) + ethyl acetate (2)} and {ethanol (1) + ethyl acetate (2)} show the most favoured solvation of MK by ethyl acetate at 298.15 K and 293.15 K, respectively. When {isopropanol (1) + ethyl acetate (2)} is combined; it is maximum at 298.15 K. Since the δx1,3 values are positive, MK preferentially solvates with ethyl acetate. The most significant values for x1 = 0.18–0.40 are obtained towards the non-polar regions of MK for the three co-solvent mixes.KEYWORDS: Musk ketoneco-solvent + ethyl acetate mixturesinverse Kirkwood–Buff integrals (IKBI)preferential salvation AcknowledgmentsThe authors extend their appreciation to the Deputyship of Scientific Research at Northern Border University, Arar, KSA for funding this research work through the project number “NBU-FFR-2023-0085.ˮDisclosure statementNo potential conflict of interest was reported by the authors.Supplementary materialSupplemental data for this article can be accessed online at https://doi.org/10.1080/00319104.2023.2275319Additional informationFundingThe work was supported by the Deputyship of Scientific Research at Northern Border University [NBU-FFR-2023-0085].