快速溶解薄膜:综述

Mansi Thakur, Isha Sharma, Michi Moda, Neha Sharma
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引用次数: 0

摘要

口服快速溶解薄膜是一种新的治疗选择,适用于吞咽药片或药片有困难的人。亲水聚合物被用来制造一种能在舌头上快速溶解的薄膜。在所有剂型中,高达50-60%的传统剂型(片剂和胶囊)被广泛接受。对于三叉神经痛、梅尼埃氏病和成瘾等疾病,任何口腔给药解决方案都已商业化或正在建议中。这种被称为口服快速溶解膜的药物输送系统在放入口腔后几秒钟内就会溶解或分解,而不需要水。膜是非建设性的,良好的黏附性。用于制造快速溶解薄膜的方法有溶剂铸造法、轧制法。速溶膜的评价试验是硬度、脆性。快速溶膜是一种新的口服给药技术。它是用透皮贴片的技术制造的。采用喷雾干燥法和冷冻干燥法制备快溶片。通过创造一种易于使用的剂型,新型药物传递系统(NDDS)有望提高目前使用药物分子的安全性和有效性,改善患者的依从性和更好的管理。要创造一个化学实体,需要大量的金钱、精力和时间。在需要快速行动的情况下是有益的,比如晕车、严重不适、过敏反应或咳嗽。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fast Dissolving Films: A Review
Fast dissolving films for oral administration were a novel treatment option for individuals who had trouble swallowing pills or tablets. Hydrophilic polymers are used to create a film that quickly dissolves on the tongue. Upto 50-60% of all dosage forms, the traditional dosage forms (tablet and capsule) are widely accepted. For condition such as trigeminal neuralgia, Meniere’s disease and addiction, any buccal administration solutions have been commercialized or are being suggested. The type of drug delivery system known as an orally fast dissolving film dissolves or disintegrates in the oral cavity after being placed there in a matter of seconds without the need for water. Films are unconstructive, excellent mucoadhesion. Methods used for manufacturing of Fast dissolving films are solvent casting method, rolling. Evaluation test for fast dissolving films are hardness, friability. A new drug delivery technology for oral drug administration is fast-dissolving film. It was created using the transdermal patch's technology. The methods employed for Spray drying and freeze-drying are used to make fast-dissolving tablets. By creating an easy-to-use dosage form, Novel Pharmacological Delivery System (NDDS), a recent advancement, promises to improve the safety and effectiveness of currently used drug molecules improved patient compliance and better administration. To create a chemical entity, it takes a lot of money, effort, and time are necessary. Beneficial in situations where an extra quick onset of action is necessary, such as motion sickness, severe discomfort, allergic reactions, or coughing.
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