Argonaute家族基因在RNA干扰激活剂依诺沙星对果蝇寿命影响中的作用

Izvestiia Sibirskogo otdeleniia sektsii nauk o Zemle Rossiiskoi akademii estestvennykh nauk Geologiia razvedka i razrabotka mestorozhdenii poleznykh iskopaemykh Pub Date : 2023-10-25 DOI:10.19110/1994-5655-2023-6-103-114

N. Pakshina, D. Yakovleva, N. Ulyasheva, E. Proshkina, A. Moskalev

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引用次数: 0

摘要

表观遗传机制在基因表达调控和生物过程协调中起主导作用，影响机体的衰老速度和寿命。在这些机制的实现中，小RNA发挥了重要作用，它们通过RNA干扰抑制自身靶标的活性并提供抗病毒保护。依诺沙星是一种独特的RNA干扰因子诱导剂，具有潜在的老年保护作用。其作用已确定是由mirna介导的，但其他类型的非编码rna也可能参与其中。在本研究中，我们研究了依诺沙星对果蝇寿命的影响，并首先分析了Argonaute家族基因对这种影响的贡献，特别是确保mirna, sirna和pirna的生物发生和功能。

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The role of genes of the Argonaute family in the effects of the RNA interference activator enoxacin on the lifespan of Drosophila melanogaster

Epigenetic mechanisms play a leading role in the regulation of gene expression and the coordination of biological processes, influencing the aging rate and the organism’s lifespan. An important role in the implementation of these mechanisms is played by small RNAs which suppress the activity of own targets through the RNA interference and provide the antiviral protection. Enoxacin is a unique inducer of RNA interference factors with potential geroprotective activity. Its effects have been identified to be mediated by miRNAs but other types of non-coding RNAs may also be involved. In this study, we have investigated the effect of enoxacin on the Drosophila melanogaster lifespan and first analyzed the contribution of Argonaute family genes to this effect which specifically ensure the biogenesis and functioning of miRNAs, siRNAs, and piRNAs.

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来源期刊

Izvestiia Sibirskogo otdeleniia sektsii nauk o Zemle Rossiiskoi akademii estestvennykh nauk Geologiia razvedka i razrabotka mestorozhdenii poleznykh iskopaemykh

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审稿时长

12 weeks