P300在周围神经病变中的作用:认知功能评估及性别影响

IF 0.8 Q4 RHEUMATOLOGY
Mohammad Mejahed, Amira M. Ibrahim, Tamer Haydara, Salma Ragab, Takwa A. Gabr
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引用次数: 0

摘要

周围神经病变(PN)患者具有可能导致认知障碍的微妙中枢病理。P300是一种认知潜能,它与感觉和认知过程都有联系。神经认知障碍患者的P300潜伏期明显更长。本研究旨在探讨P300作为PN患者早期认知能力下降的标志物的潜力,以及性别对PN患者P300的影响。结果研究组包括60名无其他神经系统疾病的各种病因PN患者,对照组包括40名听力正常、无中枢或外周听神经异常的志愿者。与对照组相比,研究组的P300反应有明显的延迟性。与女性组相比,男性组的P300潜伏期明显延迟。在P300振幅方面,男性组与女性组比较差异无统计学意义。结论虽然PN患者的认知功能明显正常,但本研究结果显示可能存在细微的认知功能障碍。认知功能在轴突PN和脱髓鞘PN中都受到影响,但在两个亚组之间没有发现差异。听觉诱发电位,特别是P300可以很容易地用于亚临床认知障碍的早期检测,在任何神经系统症状出现之前。P300潜伏期比振幅更重要,可单独或与振幅一起用于认知功能评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
P300 in peripheral neuropathy: cognitive functions assessment and gender effect
Abstract Background Patients with peripheral neuropathy (PN) have subtle central pathology that might contribute to cognitive impairment. P300 is a cognitive potential that is connected to both sensory and cognitive processes. Subjects with neurocognitive disorders have considerably longer P300 latency. This study aims to investigate P300's potential as a marker of early-stage cognitive deterioration in PN patients and also, the effect of gender on P300 in patients with PN. Results A study group of 60 subjects with PN of various etiologies and no other neurological conditions was included, in addition to, a control group of 40 volunteers with normal hearing sensitivity and no central or peripheral auditory neurological abnormalities. P300 response showed significant delayed latencies in study group when compared to control group. Male group had significant delayed P300 latencies in comparison to female group. As regard P300 amplitude, male group showed no statistically significant differences in comparison to female group. Conclusions Although patients with PN apparently have normal cognitive function, the results in this study revealed the possibility of subtle cognitive impairment. Cognitive functions are affected in both axonal PN and demyelinating PN, however there were no differences found between the two subgroups. Auditory evoked potentials, particularly P300 can be used easily for early detection of subclinical cognitive impairment before appearance of any neurological manifestations. P300 latencies are more important than amplitudes and may be used alone or in addition to amplitudes in cognitive function assessment.
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自引率
25.00%
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