用于脑内活性氧/氮测量的电化学微纳米生物传感器

IF 6.1 3区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nanotechnology Reviews Pub Date : 2023-01-01 DOI:10.1515/ntrev-2023-0124

Fatemeh Beigloo, Samira Amiri Khoshkar-Vandi, Elham Pourmand, Mona Heydari, Fatemeh Molaabasi, Nima Gharib, Yasser Zare, Kyong Yop Rhee, Soo-Jin Park

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引用次数: 0

摘要

在这篇重点综述中，我们研究了活性氧和活性氮(ROS/RNS)对生理过程和氧化应激诱导的影响，特别强调了大脑和神经元系统。我们讨论了ROS和RNS的形成机制，它们在大脑中的意义，以及各种检测方法。本文综述了纳米工程电化学生物传感器在体内监测脑组织中活性氧和RNS的最新进展。我们探索了特定物质的电化学测量，如h2o2、超氧化物、NO和过氧亚硝酸盐，同时对大脑中ROS和RNS检测的传感器设计进行了比较评估。最后，对该领域的发展前景进行了展望和总结。

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Electrochemical micro- and nanobiosensors for in vivo reactive oxygen/nitrogen species measurement in the brain

Abstract In this focused review, we examine the influence of reactive oxygen and nitrogen species (ROS/RNS) on physiological processes and the induction of oxidative stress, with particular emphasis on the brain and neuronal systems. We discuss the formation mechanisms of ROS and RNS, their significance in the brain, and various detection methods. The review investigates the latest advancements in nano-engineered electrochemical biosensors designed for in vivo monitoring of ROS and RNS in the brain tissue. We explore the electrochemical measurement of specific species, such as H 2 O 2 , superoxide, NO, and peroxynitrite, while providing a comparative evaluation of sensor designs for ROS and RNS detection in the brain. Finally, we offer an outlook and conclusion on the future of this field.

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来源期刊

Nanotechnology Reviews CHEMISTRY, MULTIDISCIPLINARY-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

11.40

自引率

13.50%

发文量

137

审稿时长

7 weeks

期刊介绍： The bimonthly journal Nanotechnology Reviews provides a platform for scientists and engineers of all involved disciplines to exchange important recent research on fundamental as well as applied aspects. While expert reviews provide a state of the art assessment on a specific topic, research highlight contributions present most recent and novel findings. In addition to technical contributions, Nanotechnology Reviews publishes articles on implications of nanotechnology for society, environment, education, intellectual property, industry, and politics.