Formulation and Evaluation of Transdermal Patches of Clotrimazole

The aim of the present research work was to formulate Transdermal patches of Clotrimazole and to enhance effectiveness and to avoid side effects of the drug. Transdermal patch of clotrimazole was prepared with EC and HPMC in different ratios in order to improve the drug diffusion. Clotrimazole has formulated Transdermal patches were prepared by solvent evaporation technique. Drug and polymers has been characterized by FT-IR. The FTIR spectra of formulation shows that no interaction between drug and excipient. The evaluation of Transdermal patches of Clotrimazole were performed mainly for their Physical parameters such as Weight variation, Thickness, Folding endurance test And also for their Drug content and In-vitro Drug diffusion studies. The patch prepared by solvent evaporation technique passes the prepared patch were found to be non irritant, weight variation was found in the range of 39±5.81 to 48±2.90mg, thickness in the range of 0.08±0.09 to 0.04±0.08 mm, Folding endurance of patches was found to be in the range of 98 ±0.57 to 128±0.59, The tensile strength of the patches was ranging from 1.95±1.2to 3.98±1.9, The percentage elongation ranges from 10.6 to 18.6, drug content uniformity was in between 78.25 to 89.76 %. The in-vitro drug diffusion profiles of the formulations in pH 7.4 show differences depending on their composition. A Tran’s dermal patches of all the preparations were observed by the diffusion test. It was also observed that F6 showed highest drug release.