透明质酸填充物诱导延迟性炎症反应的病因分析

IF 1.3 Q3 SURGERY
Won Lee, Sabrina Shah-Desai, Nark-Kyoung Rho, Jeongmok Cho
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引用次数: 0

摘要

透明质酸填充物引起的延迟炎症反应的病因和病理生理尚未阐明。先前的研究表明,病因可归因于透明质酸填充物本身、患者免疫状况、感染和注射技术。透明质酸填充剂由高分子量的透明质酸组成,用1,4-丁二醇二缩水甘油醚(BDDE)等物质进行化学交联。BDDE交联两种透明质酸双糖的机制尚不清楚,它可能以完全反应交联剂、悬垂交联剂、失活交联剂和残留交联剂的形式存在。透明质酸填料在制造过程中还含有硅油、铝等杂质。当透明质酸填充剂注入体内时,杂质会引起异物反应。在进行无菌透明质酸填充剂注射时,应考虑生物膜形成或延迟炎症反应的可能性。当患者出现流感样疾病时,往往会出现延迟性炎症反应;因此,患者的免疫状态在延迟性炎症反应中起着重要作用。大剂量透明质酸填充剂注射可诱发异物反应,形成肉芽肿的风险相对较高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Etiology of delayed inflammatory reaction induced by hyaluronic acid filler
The etiology and pathophysiology of delayed inflammatory reactions caused by hyaluronic acid fillers have not yet been elucidated. Previous studies have suggested that the etiology can be attributed to the hyaluronic acid filler itself, patient immunological status, infection, and injection technique. Hyaluronic acid fillers are composed of high-molecular-weight hyaluronic acids that are chemically crosslinked using substances such as 1,4-butanediol diglycidyl ether (BDDE). The mechanism by which BDDE crosslinks the two hyaluronic acid disaccharides is still unclear and it may exist as a fully reacted crosslinker, pendant crosslinker, deactivated crosslinker, and residual crosslinker. The hyaluronic acid filler also contains impurities such as silicone oil and aluminum during the manufacturing process. Impurities can induce a foreign body reaction when the hyaluronic acid filler is injected into the body. Aseptic hyaluronic acid filler injections should be performed while considering the possibility of biofilm formation or delayed inflammatory reaction. Delayed inflammatory reactions tend to occur when patients experience flu-like illnesses; thus, the patient’s immunological status plays an important role in delayed inflammatory reactions. Large-bolus hyaluronic acid filler injections can induce foreign body reactions and carry a relatively high risk of granuloma formation.
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来源期刊
CiteScore
2.10
自引率
6.70%
发文量
131
审稿时长
10 weeks
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