CYP1A2基因多态性(rs762551)与风险的关系 乳腺癌和第一次怀孕流产的风险

Q4 Medicine
Olga N. Gulyaeva, Anastasiуa S. Kazitskaya, Evgeniya V. Ulanova, Sergey V. Matoshin, Mariya V. Chifranova, Lyudmila V. Renge, Svetlana V. Shramko
{"title":"CYP1A2基因多态性(rs762551)与风险的关系
乳腺癌和第一次怀孕流产的风险","authors":"Olga N. Gulyaeva, Anastasiуa S. Kazitskaya, Evgeniya V. Ulanova, Sergey V. Matoshin, Mariya V. Chifranova, Lyudmila V. Renge, Svetlana V. Shramko","doi":"10.47470/0016-9900-2023-102-8-848-852","DOIUrl":null,"url":null,"abstract":"Introduction. Missed pregnancy, as a rule, is caused by a combination of several factors. Exogenous factors can have a teratogenic effect, leading to the occurrence of mutations of varying severity. In such case at the early stages of embryogenesis, serious disturbances occur, leading to a halt in the pregnancy development. The system of their biotransformation is responsible for the elimination of xenobiotics from the body, the inadequate functioning of which increases the activity of mutagenesis, which may raise the risk of breast cancer.
 Materials and methods. One hundred thirty four women were examined. The first group included 63 women, 28 of them were diagnosed with fetal egg death in primigravida young women, in 35 women the first pregnancy ended with physiological childbirth. The second group included 71 woman, 33 of them were diagnosed with a malignant breast neoplasm, 38 had no suspicion of breast cancer (BC) according to the results of mammography. Polymorphisms of the CYP1A2*1F gene of the xenobiotic biotransformation system in these groups were determined by polymerase chain reaction.
 Results. In the group of women with a missed first pregnancy, a statistically reliable association of a high risk of the fetal egg death with the A/A CYP1A2*1F genotype and resistance to this pathology in the case of the C/A CYP1A2*1F polymorphism was revealed. In the group of BC women, the association of a high risk of developing a malignant neoplasm with the A/A CYP1A2*1F genotype and resistance to the development of the disease in the presence of C/A CYP1A2*1F polymorphism was shown.
 Limitations. The study was limited by the number of samples, there is no data on polymorphisms of the BRCA-1, BRCA-2 genes.
 Conclusion. The results obtained will allow not only adjusting the tactics of pregnancy management in women with a high risk of the fetal egg death or the selection of pharmacological drugs in the treatment of BC under the conditions of serious environmental stress, but also developing preventive measures to reduce the risk of these pathologies.","PeriodicalId":12550,"journal":{"name":"Gigiena i sanitariia","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association of CYP1A2 gene polymorphism (rs762551) with the risk 
 of breast cancer and miscarriage of the first pregnancy\",\"authors\":\"Olga N. Gulyaeva, Anastasiуa S. Kazitskaya, Evgeniya V. Ulanova, Sergey V. Matoshin, Mariya V. Chifranova, Lyudmila V. Renge, Svetlana V. Shramko\",\"doi\":\"10.47470/0016-9900-2023-102-8-848-852\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction. Missed pregnancy, as a rule, is caused by a combination of several factors. Exogenous factors can have a teratogenic effect, leading to the occurrence of mutations of varying severity. In such case at the early stages of embryogenesis, serious disturbances occur, leading to a halt in the pregnancy development. The system of their biotransformation is responsible for the elimination of xenobiotics from the body, the inadequate functioning of which increases the activity of mutagenesis, which may raise the risk of breast cancer.
 Materials and methods. One hundred thirty four women were examined. The first group included 63 women, 28 of them were diagnosed with fetal egg death in primigravida young women, in 35 women the first pregnancy ended with physiological childbirth. The second group included 71 woman, 33 of them were diagnosed with a malignant breast neoplasm, 38 had no suspicion of breast cancer (BC) according to the results of mammography. Polymorphisms of the CYP1A2*1F gene of the xenobiotic biotransformation system in these groups were determined by polymerase chain reaction.
 Results. In the group of women with a missed first pregnancy, a statistically reliable association of a high risk of the fetal egg death with the A/A CYP1A2*1F genotype and resistance to this pathology in the case of the C/A CYP1A2*1F polymorphism was revealed. In the group of BC women, the association of a high risk of developing a malignant neoplasm with the A/A CYP1A2*1F genotype and resistance to the development of the disease in the presence of C/A CYP1A2*1F polymorphism was shown.
 Limitations. The study was limited by the number of samples, there is no data on polymorphisms of the BRCA-1, BRCA-2 genes.
 Conclusion. The results obtained will allow not only adjusting the tactics of pregnancy management in women with a high risk of the fetal egg death or the selection of pharmacological drugs in the treatment of BC under the conditions of serious environmental stress, but also developing preventive measures to reduce the risk of these pathologies.\",\"PeriodicalId\":12550,\"journal\":{\"name\":\"Gigiena i sanitariia\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-10-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gigiena i sanitariia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.47470/0016-9900-2023-102-8-848-852\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gigiena i sanitariia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.47470/0016-9900-2023-102-8-848-852","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

摘要

介绍。通常,漏孕是由多种因素共同造成的。外源因素可具有致畸作用,导致不同程度突变的发生。在这种情况下,在胚胎发生的早期阶段,发生严重的干扰,导致妊娠发育停止。它们的生物转化系统负责消除体内的外来生物,其功能不足会增加诱变的活性,这可能会增加患乳腺癌的风险。材料和方法。134名妇女接受了检查。第一组包括63名妇女,其中28名初产妇被诊断为胎卵死亡,35名妇女首次怀孕以生理分娩结束。第二组71名妇女,其中33名诊断为乳腺恶性肿瘤,38名根据乳房x光检查结果未怀疑为乳腺癌(BC)。采用聚合酶链反应测定各组异种生物转化系统CYP1A2*1F基因多态性。 结果。在首次妊娠未成功的妇女组中,揭示了a / a CYP1A2*1F基因型和C/ a CYP1A2*1F基因型对这种病理的耐药性与胎卵死亡的高风险有统计学可靠的关联。在BC组女性中,a / a CYP1A2*1F基因型和C/ a CYP1A2*1F多态性与恶性肿瘤发展的高风险相关。 的局限性。受样本数量的限制,没有BRCA-1、BRCA-2基因多态性的数据。 结论。所获得的结果不仅可以调整胎卵死亡高风险妇女的妊娠管理策略或在严重环境应激条件下治疗BC的药物选择,而且还可以制定预防措施以降低这些病理的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of CYP1A2 gene polymorphism (rs762551) with the risk of breast cancer and miscarriage of the first pregnancy
Introduction. Missed pregnancy, as a rule, is caused by a combination of several factors. Exogenous factors can have a teratogenic effect, leading to the occurrence of mutations of varying severity. In such case at the early stages of embryogenesis, serious disturbances occur, leading to a halt in the pregnancy development. The system of their biotransformation is responsible for the elimination of xenobiotics from the body, the inadequate functioning of which increases the activity of mutagenesis, which may raise the risk of breast cancer. Materials and methods. One hundred thirty four women were examined. The first group included 63 women, 28 of them were diagnosed with fetal egg death in primigravida young women, in 35 women the first pregnancy ended with physiological childbirth. The second group included 71 woman, 33 of them were diagnosed with a malignant breast neoplasm, 38 had no suspicion of breast cancer (BC) according to the results of mammography. Polymorphisms of the CYP1A2*1F gene of the xenobiotic biotransformation system in these groups were determined by polymerase chain reaction. Results. In the group of women with a missed first pregnancy, a statistically reliable association of a high risk of the fetal egg death with the A/A CYP1A2*1F genotype and resistance to this pathology in the case of the C/A CYP1A2*1F polymorphism was revealed. In the group of BC women, the association of a high risk of developing a malignant neoplasm with the A/A CYP1A2*1F genotype and resistance to the development of the disease in the presence of C/A CYP1A2*1F polymorphism was shown. Limitations. The study was limited by the number of samples, there is no data on polymorphisms of the BRCA-1, BRCA-2 genes. Conclusion. The results obtained will allow not only adjusting the tactics of pregnancy management in women with a high risk of the fetal egg death or the selection of pharmacological drugs in the treatment of BC under the conditions of serious environmental stress, but also developing preventive measures to reduce the risk of these pathologies.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Gigiena i sanitariia
Gigiena i sanitariia Environmental Science-Pollution
CiteScore
0.80
自引率
0.00%
发文量
192
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信