印度尼西亚人群ADAM33基因rs2787094遗传变异与哮喘的关系:初步研究

IF 0.3 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Kencono Viyati
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引用次数: 0

摘要

背景:哮喘是一种多因素疾病,包括多种遗传和环境因素。其中一个因素是崩解素和金属蛋白33 (ADAM33)基因,它与哮喘和支气管高反应性有关。先前对亚洲人群进行的研究报道了ADAM33基因rs2787094多态性与哮喘之间的显著关联。方法:我们的研究纳入了153名印度尼西亚参与者。采用TaqMan基因分型法分析ADAM33基因rs2787094多态性。结果:rs2787094等位基因和基因型频率与病例和对照组哮喘无显著相关性(p = 1.00)。健康对照组rs2787094基因型分布为CC(12.1%)、CG(42.1%)和GG(45.8%)。在1000个基因组数据集中,印度尼西亚人的基因型分布与东亚人相似。结论:本研究首次对印度尼西亚人群中ADAM33基因rs2787094多态性与哮喘的相关性进行了研究,并得出了不相关的结论。未来需要更大样本量和更多ADAM33基因单核苷酸多态性的研究来验证这些结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between rs2787094 Genetic Variants in ADAM33 Gene and Asthma in Indonesian Population: Preliminary study
Background: Asthma is a multifactorial disease that encompasses a multitude of genetic and environmental factors. One such factor is the disintegrin and metalloprotein-33 (ADAM33) gene, which is correlated with asthma and bronchial hyperresponsiveness. Previous studies conducted on Asian populations have reported a significant association between rs2787094 polymorphism in the ADAM33 gene and asthma. Methods: Our study involved 153 Indonesian participants. TaqMan genotyping assay was used to analyze rs2787094 polymorphism in the ADAM33 gene. Results: No significant association was detected between the allele and genotype frequencies of rs2787094 and asthma in the case and control subjects (p = 1.00). The distribution of rs2787094 genotypes in healthy controls was CC (12.1%), CG (42.1%), and GG (45.8%). The genotype distribution in Indonesians was similar to East Asians in 1,000 genomes dataset. Conclusions: This is the first study to investigate the association between rs2787094 polymorphism in the ADAM33 gene and asthma in the Indonesian population and concluded that it is not associated. Future studies with larger sample sizes and more single nucleotide polymorphisms in the ADAM33 gene are needed to validate these results.
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来源期刊
Makara Journal of Health Research
Makara Journal of Health Research MEDICINE, RESEARCH & EXPERIMENTAL-
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