肠沙门氏菌产生的不同类型金属蛋白的研究进展

IF 2.1 Q3 MICROBIOLOGY

Microbiology Research Pub Date : 2023-09-19 DOI:10.3390/microbiolres14030099

Yehya Mohsen, Nathalie Tarchichi, Rana Barakat, Inas Kawtharani, Rayane Ghandour, Zeinab Ezzeddine, Ghassan Ghssein

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引用次数: 0

摘要

肠炎沙门氏菌(S. enterica)血清型肠炎和鼠伤寒沙门氏菌是世界范围内细菌性肠胃炎的主要病因。这种革兰氏阴性杆状细菌具有几种毒力因子，使其能够在宿主的营养免疫中存活。毒素和金属细胞是这些因素之一。特别是重金属，对包括细菌在内的所有生物体的生存至关重要。在感染过程中，肠球菌通过分泌次生代谢产物金属蛋白与宿主竞争可利用的重金属。一旦在细胞外培养基中产生，金属载体就会使重金属复杂化，从而使沙门氏菌能够通过嵌入其膜中的通道获取金属离子。本文就该细菌合成的各种金属细胞的生物合成、输出、输入及遗传调控作一综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Different Types of Metallophores Produced by Salmonella enterica: A Review

Salmonella enterica (S. enterica) serovars Enteritidis and Typhimurium are the main causes of bacterial gastroenteritis worldwide. This Gram-negative rods bacterium possesses several virulence factors that enable it to survive the host’s nutritional immunity. Toxins and metallophores are among these factors. Heavy metals, in particular, are essential for the survival of all living organisms including bacteria. During infection, S. enterica competes with the host for the available heavy metals by secreting metallophores, which are secondary metabolites. Once produced in the extracellular medium, metallophores complex heavy metals thus allowing Salmonella to acquire metal ions through importing them via channels embedded in their membranes. This review highlights the biosynthesis, export, import, and genetic regulation of different metallophores synthesized by this germ.

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来源期刊

Microbiology Research MICROBIOLOGY-

CiteScore

1.90

自引率

6.70%

发文量

审稿时长

10 weeks

期刊介绍： Microbiology Research is an international, online-only, open access peer-reviewed journal which publishes original research, review articles, editorials, perspectives, case reports and brief reports to benefit researchers, microbiologists, physicians, veterinarians. Microbiology Research publishes ‘Clinic’ and ‘Research’ papers divided into two different skill and proficiency levels: ‘Junior’ and ‘Professional’. The aim of this four quadrant grid is to encourage younger researchers, physicians and veterinarians to submit their results even if their studies encompass just a limited set of observations or rely on basic statistical approach, yet upholding the customary sound approach of every scientific article.