低温大气等离子体沉积抗生素在钛表面及其洗脱液对金黄色葡萄球菌生长的影响。

Q3 Physics and Astronomy

Plasma Medicine Pub Date : 2023-01-01 DOI:10.1615/plasmamed.2023050382

Beatrice Olayiwola, Fiona O'Neill, Darren Kavanagh, Liam O'Neill, Rosemary O'Hara

{"title":"低温大气等离子体沉积抗生素在钛表面及其洗脱液对金黄色葡萄球菌生长的影响。","authors":"Beatrice Olayiwola, Fiona O'Neill, Darren Kavanagh, Liam O'Neill, Rosemary O'Hara","doi":"10.1615/plasmamed.2023050382","DOIUrl":null,"url":null,"abstract":"Cold atmospheric plasma (CAP) was used to deposit antibiotics, penicillin, and ciprofloxacin, separately onto titanium coupons. The antibiotic coating parameters were varied using a design of experiment software which factored in plasma power, bacterial and antibiotic load. The antimicrobial activity of the plasma deposited antibiotics was benchmarked against conventional spray coated materials and the effect of the plasma exposure is discussed. The deposited antibiotics were characterized using various surface analysis and microbiological techniques. It was found that the antibiotics were not degraded and retained antibiotic activity against planktonic staphylococcus aureus bacteria. However, the presence of the plasma during coating did alter the elution profile of the antibiotics and helped prolong the activity of the antibiotics on the metal surface. This study may contribute to the development of novel implant coating procedures that can offer prolonged antimicrobial protection.","PeriodicalId":53607,"journal":{"name":"Plasma Medicine","volume":"156 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The efficacy of cold atmospheric plasma deposited antibiotics on titanium surfaces and their elution liquids against Staphylococcus Aureus growth over time.\",\"authors\":\"Beatrice Olayiwola, Fiona O'Neill, Darren Kavanagh, Liam O'Neill, Rosemary O'Hara\",\"doi\":\"10.1615/plasmamed.2023050382\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Cold atmospheric plasma (CAP) was used to deposit antibiotics, penicillin, and ciprofloxacin, separately onto titanium coupons. The antibiotic coating parameters were varied using a design of experiment software which factored in plasma power, bacterial and antibiotic load. The antimicrobial activity of the plasma deposited antibiotics was benchmarked against conventional spray coated materials and the effect of the plasma exposure is discussed. The deposited antibiotics were characterized using various surface analysis and microbiological techniques. It was found that the antibiotics were not degraded and retained antibiotic activity against planktonic staphylococcus aureus bacteria. However, the presence of the plasma during coating did alter the elution profile of the antibiotics and helped prolong the activity of the antibiotics on the metal surface. This study may contribute to the development of novel implant coating procedures that can offer prolonged antimicrobial protection.\",\"PeriodicalId\":53607,\"journal\":{\"name\":\"Plasma Medicine\",\"volume\":\"156 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Plasma Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1615/plasmamed.2023050382\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Physics and Astronomy\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Plasma Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1615/plasmamed.2023050382","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Physics and Astronomy","Score":null,"Total":0}

引用次数: 0

摘要

低温常压等离子体(CAP)将抗生素、青霉素和环丙沙星分别沉积在钛片上。采用考虑等离子体功率、细菌和抗生素负荷的实验软件设计改变抗生素包被参数。对等离子体沉积抗生素的抑菌活性进行了对比，并对等离子体暴露的影响进行了讨论。使用各种表面分析和微生物学技术对沉积的抗生素进行了表征。结果表明，抗菌药物不降解，对浮游金黄色葡萄球菌仍具有抗菌活性。然而，在涂层过程中等离子体的存在确实改变了抗生素的洗脱谱，并有助于延长抗生素在金属表面的活性。这项研究可能有助于发展新的种植体涂层程序，可以提供长期的抗菌保护。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

The efficacy of cold atmospheric plasma deposited antibiotics on titanium surfaces and their elution liquids against Staphylococcus Aureus growth over time.

Cold atmospheric plasma (CAP) was used to deposit antibiotics, penicillin, and ciprofloxacin, separately onto titanium coupons. The antibiotic coating parameters were varied using a design of experiment software which factored in plasma power, bacterial and antibiotic load. The antimicrobial activity of the plasma deposited antibiotics was benchmarked against conventional spray coated materials and the effect of the plasma exposure is discussed. The deposited antibiotics were characterized using various surface analysis and microbiological techniques. It was found that the antibiotics were not degraded and retained antibiotic activity against planktonic staphylococcus aureus bacteria. However, the presence of the plasma during coating did alter the elution profile of the antibiotics and helped prolong the activity of the antibiotics on the metal surface. This study may contribute to the development of novel implant coating procedures that can offer prolonged antimicrobial protection.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Plasma Medicine Physics and Astronomy-Physics and Astronomy (all)

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： Technology has always played an important role in medicine and there are many journals today devoted to medical applications of ionizing radiation, lasers, ultrasound, magnetic resonance and others. Plasma technology is a relative newcomer to the field of medicine. Experimental work conducted at several major universities, research centers and companies around the world over the recent decade demonstrates that plasma can be used in variety of medical applications. It is already widely used surgeries and endoscopic procedures. It has been shown to control properties of cellular and tissue matrices, including biocompatibility of various substrates. Non-thermal plasma has been demonstrated to deactivate dangerous pathogens and to stop bleeding without damaging healthy tissue. It can be used to promote wound healing and to treat cancer. Understanding of various mechanisms by which plasma can interact with living systems, including effects of reactive oxygen species, reactive nitrogen species and charges, has begun to emerge recently. The aim of the Plasma Medicine journal will be to provide a forum where the above topics as well as topics closely related to them can be presented and discussed. Existing journals on plasma science and technology are aimed for audiences with primarily engineering and science background. The field of Plasma Medicine, on the other hand, is highly interdisciplinary. Some of prospective readers and contributors of the Plasma Medicine journal are expected to have background in medicine and biology. Others might be more familiar with plasma science. The goal of the proposed Plasma Medicine journal is to bridge the gap between audiences with such different backgrounds, without sacrificing the quality of the papers be their emphasis on medicine, biology or plasma science and technology.