SORPTION OF CADMIUM AND LEAD WITH SUBSTANCES PROMISING FOR THE CREATION OF COMPOSITE PREPARATIONS BASED ON HEXACYANOFERRATES

The development of new drugs and feed additives to reduce the accumulation of anthropogenic and natural toxicants (heavy metals, radionuclides, mycotoxins, pesticides, etc.) in the body of farm animals and livestock products remains an urgent task. One of the ways to solve it is to create multifunctional products containing ferrocyanides (hexacyanoferrates) of transition metals as active substances. In medicine and veterinary medicine, enterosorbents based on compounds of this class are used as independent pharmacological agents, and in the form of composite preparations, which are obtained by fixing ferrocyanides on carrier substances of different origin and chemical composition. To study the possibility of using certain substances as carriers in the creation of new composite preparations and to assess their effect on the detoxification properties of ferrocyanides, the sorption efficiency of a number of mineral and organic substances with respect to Cd and Pb was studied. It was found that the background content of Cd and Pb in the tested substances does not exceed the maximum permissible levels of these toxicants in feed, feed additives and veterinary preparations. Under in vitro conditions, the biomass of the fungus Inonotus obliquus (chaga), the preparations ferrocin, bifezh and KhZh-90, zeolite tuff shivyrtuin, smectite dioctahedral, white soot and chitosan succinate have the greatest efficiency of Cd and Pb sorption (with respect to Cd – 50.4-89.0%, Pb – 58.3-95.1%). The combined presence of Cd and Pb reduces the sorption capacity of most of the tested substances by 1.6-63.6%.