An Ecofriendly Novel Spectrophotometric Estimation and Validation of Meloxicam in Bulk Drug and their Dosage Form by mixed Hydrotropic Solubilization Method

Solubility is a crucial factor during estimation of poorly soluble drugs. Literature survey reveals spectrophotometric estimation of poorly soluble drugs are mostly done by employing organic solvents. The drawbacks of organic solvents include higher cost, toxicity, pollution and error due to volatility. Hydrotropic solubilisation method involves increasing the solubility of a poorly soluble drug in water with the addition of hydrotropic agents. Most of NSAIDs like Meloxicam, Mefenamic acid, Aceclofenacetc are poorly soluble in water. Meloxicam was found to be soluble in mixed hydrotropic solution of 10% sodium benzoate and 10% sodium caprylate with maximum absorbance at 364 nm. The developed method was found to be linear in the range of 2-10 µg/ml with correlation coefficient (R2) of 0.9968. The LOD and LOQ of proposed method was found to be 0.2634 µg/ml and 0.7983 µg/ml respectively. A novel, simple, safe, sensitive and cost-effective spectrophotometric estimation method was developed for estimation of Meloxicam using 10% sodium benzoate and 10% sodium caprylate as hydrotropic agent. This solubilization method can be employed to preclude the use of organic solvents for the estimation of poorly soluble drugs.