Gayuh Prastya Masdiyanto, None Agung Muda Patih, None Erial Bahar
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 Methods: This study is a prospective prognostic test study to test the sensitivity and specificity of D-dimer for prediction mortality in patients with severe head injuries at Dr. Mohammad Hoesin General Hospital (RSMH) Palembang in the period June 2023 to August 2023. A total of 47 research subjects participated in this study.
 Results: Post 24-hour D-dimer levels have a cut-off point of 11.78 mg/L, which has high accuracy in poor outcomes. D-dimer levels after 5 days have a cut-off point value of 2.3 mg/L and have high sensitivity in predicting poor outcomes, and the value of the difference in changes in D-dimer based on poor outcome patients have a cut-off point of 3.33 mg/L, which has a high sensitivity in predicting a poor prognosis.
 Conclusion: D-dimer levels are quite accurate as a predictive biomarker for outcomes in head injury patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.","PeriodicalId":481706,"journal":{"name":"Sriwijaya Journal of Surgery","volume":"39 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Accuracy of D-dimer as a Predictive Biomarker for Outcome in Head Injured Patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia\",\"authors\":\"Gayuh Prastya Masdiyanto, None Agung Muda Patih, None Erial Bahar\",\"doi\":\"10.37275/sjs.v6i2.95\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: D-dimer reflects the upregulation of the overall hemostatic system upon admission. If D-dimer levels increase, coagulation disorders appear. This is considered a poor prognostic factor. High D-dimer levels reflect the severity of brain injury. Activation of systemic coagulation causes extensive intravascular fibrin deposition and a decrease in platelets and coagulation factors. This study aimed to assess the accuracy of D-dimer as a predictive biomarker for outcomes in head injury patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.
 Methods: This study is a prospective prognostic test study to test the sensitivity and specificity of D-dimer for prediction mortality in patients with severe head injuries at Dr. Mohammad Hoesin General Hospital (RSMH) Palembang in the period June 2023 to August 2023. A total of 47 research subjects participated in this study.
 Results: Post 24-hour D-dimer levels have a cut-off point of 11.78 mg/L, which has high accuracy in poor outcomes. D-dimer levels after 5 days have a cut-off point value of 2.3 mg/L and have high sensitivity in predicting poor outcomes, and the value of the difference in changes in D-dimer based on poor outcome patients have a cut-off point of 3.33 mg/L, which has a high sensitivity in predicting a poor prognosis.
 Conclusion: D-dimer levels are quite accurate as a predictive biomarker for outcomes in head injury patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.\",\"PeriodicalId\":481706,\"journal\":{\"name\":\"Sriwijaya Journal of Surgery\",\"volume\":\"39 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-10-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sriwijaya Journal of Surgery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.37275/sjs.v6i2.95\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sriwijaya Journal of Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37275/sjs.v6i2.95","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
简介:d -二聚体反映了入院时整体止血系统的上调。如果d -二聚体水平升高,就会出现凝血功能障碍。这被认为是预后不良的因素。高d -二聚体水平反映了脑损伤的严重程度。全身凝血的激活引起广泛的血管内纤维蛋白沉积和血小板和凝血因子的减少。这项研究的目的是评估d -二聚体作为预测脑损伤患者预后的生物标志物的准确性,该生物标志物来自印度尼西亚巨港的Dr. Mohammad Hoesin总医院。方法:本研究是一项前瞻性预后试验研究,旨在测试d -二聚体预测2023年6月至2023年8月期间在Palembang Dr. Mohammad Hoesin General Hospital (RSMH)重度颅脑损伤患者死亡率的敏感性和特异性。共有47名研究对象参与了本研究。
结果:24小时后d -二聚体水平的临界值为11.78 mg/L,对不良预后有较高的准确性。5天后d -二聚体水平的分界点值为2.3 mg/L,预测不良预后的敏感性较高;基于不良预后患者的d -二聚体变化差异值的分界点为3.33 mg/L,预测不良预后的敏感性较高。
结论:d -二聚体水平作为预测印尼巨港Dr. Mohammad Hoesin总医院头部损伤患者预后的生物标志物是相当准确的。
Accuracy of D-dimer as a Predictive Biomarker for Outcome in Head Injured Patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia
Introduction: D-dimer reflects the upregulation of the overall hemostatic system upon admission. If D-dimer levels increase, coagulation disorders appear. This is considered a poor prognostic factor. High D-dimer levels reflect the severity of brain injury. Activation of systemic coagulation causes extensive intravascular fibrin deposition and a decrease in platelets and coagulation factors. This study aimed to assess the accuracy of D-dimer as a predictive biomarker for outcomes in head injury patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.
Methods: This study is a prospective prognostic test study to test the sensitivity and specificity of D-dimer for prediction mortality in patients with severe head injuries at Dr. Mohammad Hoesin General Hospital (RSMH) Palembang in the period June 2023 to August 2023. A total of 47 research subjects participated in this study.
Results: Post 24-hour D-dimer levels have a cut-off point of 11.78 mg/L, which has high accuracy in poor outcomes. D-dimer levels after 5 days have a cut-off point value of 2.3 mg/L and have high sensitivity in predicting poor outcomes, and the value of the difference in changes in D-dimer based on poor outcome patients have a cut-off point of 3.33 mg/L, which has a high sensitivity in predicting a poor prognosis.
Conclusion: D-dimer levels are quite accurate as a predictive biomarker for outcomes in head injury patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.