The impact of vaccination status on the severity of pain syndrome in COVID-19 patients of Al-Rayan Colleges, Al Madinah

COVID‐19 has a wide range of clinical features, of which pain syndrome is commonly met. Vaccination of COVID-19 reduced symptomatic infections and/or high viral load infection. The aim of this study is to compare the severity of pain syndrome among COVID-19 immunized and non-immunized patients in Al-Rayan Colleges, Al-Madinah. A retrospective cross-sectional observational study was carried out on 304 COVID-19 patients of age ranging from 18-65 years in AL-Rayan Colleges, AL-Madinah, KSA, between September 2021 to April 2023. An electronic questionnaire with 20 items was introduced to the participants of the study after filling in written consent. According to vaccine status, the participants of the study were divided into 5 groups; unvaccinated, partially vaccinated (≥ 14 d ays after dose 1 or < 14 days after dose2), Fully vaccinated (≥ 14 days after dose 2), 3rd dose vaccinated and 4th dose vaccinated. Pain syndrome symptoms were observed in all vaccinated and non-vaccinated participants with insignificant differences (P>0.05). Severe pain was highly observed in non-vaccinated participants (40.2%). While it was not detected (0%) in the 4th dose vaccinated group. It was (29.7%), (38.7%) and (39.1%) in partially vaccinated, fully vaccinated, and 3rd dose vaccine groups, respectively. In conclusion, pain syndrome was detected in all COVID-19 patients, while pain severity significantly increased in non-vaccinated patients and was absent in patients who had received the 4th dose of the vaccine.