念珠菌培养阳性的2型糖尿病患者的代谢参数

IF 10.1 2区工程技术 Q1 ENGINEERING, MECHANICAL

Facta Universitatis-Series Mechanical Engineering Pub Date : 2023-02-21 DOI:10.22190/fumb220819008r

Danijela Radojković, Jana Pešić Stanković, Milan Radojković, Vojislav Ćirić, Saša Radenković

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引用次数: 0

摘要

肠道菌群在宿主代谢、免疫、消化甚至行为中起着重要作用。念珠菌是胃肠道的常住菌，是微生物群的组成部分。该研究的目的是评估粪便中念珠菌培养阳性是否影响2型糖尿病患者的代谢参数。将46例经口服降糖治疗的2型糖尿病患者分为研究组(S=18例粪便念珠菌培养阳性患者)和对照组(C=其余28例患者)。除病史和临床检查外，对所有患者进行粪培养、空腹血糖(FPG)、糖化血红蛋白(HbA1C)、总胆固醇(CL)、甘油三酯(TG)、高密度脂蛋白(HDL)和低密度脂蛋白(LDL)检测。研究组患者BMI明显高于对照组(31.41±5.29 vs. 25.18±3.58;术中,0.001);HbA1C(9.8%±1.74 vs 6.9%±1.89;p<0.05)和FPG(10.87±1.35 vs 7.47±1.03;P<0.01)，与对照组比较。虽然研究组患者TG、CL、LDL、HDL均高于对照组，但差异无统计学意义。不受控制的血糖调节是宿主条件之一，有利于念珠菌定植和随后的感染。这可能与共生细菌的减少有关，可能是酵母与细菌竞争的结果。另一方面，我们必须记住念珠菌菌落数量的显著增加会影响碳水化合物的消化和吸收速度，从而增加糖尿病患者的血糖水平。

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METABOLIC PARAMETERS IN TYPE 2 DIABETIC PATIENTS WITH POSITIVE CANDIDA CULTURES

The gut microbiota plays an important role in host metabolism, immunity, digestibility and even behaviour. Candida spec. is common resident of the gastrointestinal tract and integral part of the microbiota. The aim of the study was to evaluate if positive Candida cultures in the stool influence metabolic parameters in type 2DM patients. 46 patients with type 2 DM and oral antidiabetic treatment, were divided into a study group (S=18 patients with positive Candida sp. cultures in stool) and the control group (C= remaining 28 patients). Besides medical history and clinical examination, all patients were tested for coproculture, fasting glycaemia (FPG), HbA1C, total cholesterol (CL) triglycerides (TG), high- density lipoproteins (HDL) and low- density lipoproteins (LDL). Study group patients had a significantly higher BMI (31.41 ± 5.29 vs. 25.18 ± 3.58; p<0.001); HbA1C (9.8 % ± 1.74 vs 6.9% ± 1.89; p<0.05) as well as FPG (10.87 ± 1.35 vs 7.47 ± 1.03; p<0.01), compared to the control group. Even though the study group patients had higher TG, CL, LDL and HDL, compared to the control group, there was no statistical significance verified. Uncontrolled glucoregulation is one of the host condition which favours candida colonization and subsequent infection. This may be related to the decrease in commensal bacteria, probably as the result of yeast-bacterial competition. On the other hand, we have to keep in mindthat a significantly increased number of Candida colonies can affect the rate of digestion and absorption of carbohydrates and consequently increase the level of glycaemia in patients with diabetes.

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来源期刊

Facta Universitatis-Series Mechanical Engineering ENGINEERING, MECHANICAL-

CiteScore

14.40

自引率

2.50%

发文量

审稿时长

6 weeks

期刊介绍： Facta Universitatis, Series: Mechanical Engineering (FU Mech Eng) is an open-access, peer-reviewed international journal published by the University of Niš in the Republic of Serbia. It publishes high-quality, refereed papers three times a year, encompassing original theoretical and/or practice-oriented research as well as extended versions of previously published conference papers. The journal's scope covers the entire spectrum of Mechanical Engineering. Papers undergo rigorous peer review to ensure originality, relevance, and readability, maintaining high publication standards while offering a timely, comprehensive, and balanced review process.