产前暴露于不同剂量泮托拉唑对白化大鼠(褐家鼠)母胎结局的影响(<i> /i>)

Anne Njoki Nyaga, Joseph Kariuki Kweri, James Mwangi Kanyoni, Ann Wairimu Mwangi, Caroline Chepng’eno Sigei, Jennifer Chepkemoi Segut, Jane Wanjiru Kuria
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摘要

泮托拉唑是一种质子泵抑制剂,用于治疗妊娠期间胃高分泌物和胃食管反流。然而,在不同的剂量和不同的妊娠期,其对母体和胎儿结局的产前影响尚未得到很好的报道。本研究采用后验式实验研究设计。本研究采用30只雌性白化大鼠作为样本。将30只白化病大鼠分为两大类:对照组3只,治疗组27只。27只给药大鼠按给药剂量分为3组,每组9只:低剂量9只,中剂量9只,高剂量9只。9只大鼠按受药时间又分为3个亚组,每组3只:妊娠1期3只,妊娠2期3只,妊娠3期3只。每天早晨记录每日母体体重,妊娠第20天人道处死所有动物,收获胎儿。连续数据包括母胎体重,离散数据包括产仔数、被吞噬胎儿数、被吸收腺体数和胚胎结石数。使用MS Excel电子表格版本13记录、编码和输入数据,并使用Windows版本25的SPSS程序进行分析(单向方差分析(ANOVA),随后进行Tukey事后多重比较检验)。结果用均数±均数标准误差(SEM)表示。P <0.05被认为在研究中具有显著性。本研究观察到,高剂量的泮托拉唑与母体平均体重增加减少、产仔数减少、子宫内膜腺吸收数量增加和吞噬胎儿有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effects of prenatal exposure to varying doses of pantoprazole on the maternal and fetal outcomes in albino rats (<i>rattus norvegicus</i>)
Pantoprazole is a proton pump inhibitor used in the management of hypergastric secretions and gastroesophageal reflux during pregnancy. However, its prenatal effects on maternal and fetal outcomes are not well reported when administered at varying doses and at different gestational periods. A post-test-only experimental study design was adopted in conducting this study. A sample size of 30 female albino rats was used for the study. The 30 albino rats were grouped into two broad study categories: 3 control rats and 27 treatment rats. The 27 treatment rats were subdivided into three study groups of nine rats each according to the doses administered as follows: 9 low-dose rats, 9 medium-dose rats, and 9 high-dose rats The nine rats assemblies were further divided up into three subgroups, each of three rats, according to the time of exposure, as follows: three rats for trimester one, three rats for trimester two, and three rats for trimester three. Daily maternal weights were recorded every morning, and then at gestation day 20, all animals were humanely sacrificed and the fetuses harvested. Continuous data included the maternal and fetal weights, and discrete data included the litter sizes, number of devoured fetuses, resorbed glands, and number of embryolithalities. Data was recorded, coded, and entered in the computer using MS Excel spreadsheets version 13, and analyzed using the SPSS programme for Windows version 25 (one-way Analysis of Variance (ANOVA) followed by Tukey’s post hoc multiple comparisons test). The results were expressed as means ± standard error of the mean (SEM). Results with a P < 0.05 were considered significant in the study. This study observed that pantoprazole, at high doses, was associated with a decrease in the mean maternal weight gain, reduced litter sizes with increased numbers of resorbed endometrial glands, and devoured fetuses.
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