An Efficient Synthesis of 1, 3-Oxazine Derivatives Catalyzed under Ceric Ammonium Nitrate in an Aqueous Medium at Ambient Temperature

We report that ceric ammonium nitrate mediated the synthesis of 1, 3-oxazine derivatives under the green method. In the reaction, 20 mol% catalysts are sufficient for the complete conversion of the reaction. The condensation reaction of β-naphthol with formaldehyde and primary amines those containing electron-donating as well as electron-withdrawing substituents under the aqueous reaction condition at ambient temperature in the presence of ceric ammonium nitrate has been developed as an efficient and eco-friendly precursor for the determination of 1, 3-oxazine derivatives. This approach has numerous benefits beyond conventional systems, notably ease of use, expense, reusability of the catalyst, and faster reaction times.