干磨和湿磨对尼莫地平- hpmc纳米颗粒溶液和溶出率的影响

IF 0.7 Q4 PHARMACOLOGY & PHARMACY
Muthia Fadhila
{"title":"干磨和湿磨对尼莫地平- hpmc纳米颗粒溶液和溶出率的影响","authors":"Muthia Fadhila","doi":"10.22146/ijp.7267","DOIUrl":null,"url":null,"abstract":"Nimodipine is a dihydropyridine calcium channel blocker that shares the general properties of nifedipine, but acts mainly on cerebral blood vessels. Nimodipine belongs to the Class II Biopharmaceutical Classification System (BCS) drug group, which has low solubility and high permeability. The purpose of this study was to look at the differences in the yield of nanoparticles between the dry grinding and wet grinding methods on the physicochemical properties, solubility, and dissolution rate of nimodipine nanoparticles. The nanoparticles were prepared a nimodipine: HPMC ratio of 1:0.6 using two different methods. Sample characterization was carried out using Particle Size Analyzer (PSA), Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), X-ray Diffraction (XRD), and Fourier Transform Infrared (FT-IR). The Solubility test was carried out in CO2-free distilled water and the dissolution rate was carried out in phosphate buffer pH 7.2. The solubility of pure nimodipine in CO2-free distilled water was 0.339 µg/mL, the physical mixture was 1.948 µg/mL, the dry grinding nanoparticles were 3.367 µg/mL, and the wet grinding nanoparticles were 19.952 µg/mL. The dissolution test results obtained with the percentage of pure nimodipine dissolution at 60th minutes was 33.947%, the physical mixture was 39.482%, the dry grinding nanoparticles were 49.798%, and the wet grinding nanoparticles were 56.484%. Based on the results of the study, it can be said that the nimodipine-HPMC nanoparticles significantly increased the solubility and dissolution rate of nimodipine.","PeriodicalId":13520,"journal":{"name":"INDONESIAN JOURNAL OF PHARMACY","volume":null,"pages":null},"PeriodicalIF":0.7000,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effectiveness of Dry Grinding and Wet Grinding Methods on Solution and Dissolution Rate of Nimodipine-HPMC Nanoparticles\",\"authors\":\"Muthia Fadhila\",\"doi\":\"10.22146/ijp.7267\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Nimodipine is a dihydropyridine calcium channel blocker that shares the general properties of nifedipine, but acts mainly on cerebral blood vessels. Nimodipine belongs to the Class II Biopharmaceutical Classification System (BCS) drug group, which has low solubility and high permeability. The purpose of this study was to look at the differences in the yield of nanoparticles between the dry grinding and wet grinding methods on the physicochemical properties, solubility, and dissolution rate of nimodipine nanoparticles. The nanoparticles were prepared a nimodipine: HPMC ratio of 1:0.6 using two different methods. Sample characterization was carried out using Particle Size Analyzer (PSA), Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), X-ray Diffraction (XRD), and Fourier Transform Infrared (FT-IR). The Solubility test was carried out in CO2-free distilled water and the dissolution rate was carried out in phosphate buffer pH 7.2. The solubility of pure nimodipine in CO2-free distilled water was 0.339 µg/mL, the physical mixture was 1.948 µg/mL, the dry grinding nanoparticles were 3.367 µg/mL, and the wet grinding nanoparticles were 19.952 µg/mL. The dissolution test results obtained with the percentage of pure nimodipine dissolution at 60th minutes was 33.947%, the physical mixture was 39.482%, the dry grinding nanoparticles were 49.798%, and the wet grinding nanoparticles were 56.484%. Based on the results of the study, it can be said that the nimodipine-HPMC nanoparticles significantly increased the solubility and dissolution rate of nimodipine.\",\"PeriodicalId\":13520,\"journal\":{\"name\":\"INDONESIAN JOURNAL OF PHARMACY\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2023-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"INDONESIAN JOURNAL OF PHARMACY\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.22146/ijp.7267\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"INDONESIAN JOURNAL OF PHARMACY","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22146/ijp.7267","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0

摘要

尼莫地平是一种二氢吡啶钙通道阻滞剂,具有硝苯地平的一般特性,但主要作用于脑血管。尼莫地平属于生物药品分类系统(BCS)ⅱ类药物,具有低溶解度和高渗透性。本研究的目的是观察干式研磨和湿式研磨对尼莫地平纳米颗粒的理化性质、溶解度和溶出率的影响。采用两种不同的方法制备尼莫地平与HPMC的比例为1:6 .6的纳米颗粒。采用粒度分析仪(PSA)、扫描电镜(SEM)、差示扫描量热法(DSC)、x射线衍射(XRD)和傅里叶变换红外(FT-IR)对样品进行表征。在无co2蒸馏水中进行溶解度测试,在pH 7.2的磷酸盐缓冲液中进行溶解率测试。纯尼莫地平在无co2蒸馏水中的溶解度为0.339µg/mL,物理混合物的溶解度为1.948µg/mL,干磨纳米颗粒的溶解度为3.367µg/mL,湿磨纳米颗粒的溶解度为19.952µg/mL。60分钟尼莫地平纯溶出度为33.947%,物理混合物溶出度为39.482%,干磨纳米颗粒为49.798%,湿磨纳米颗粒为56.484%。根据研究结果,可以说尼莫地平- hpmc纳米颗粒显著提高了尼莫地平的溶解度和溶出率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effectiveness of Dry Grinding and Wet Grinding Methods on Solution and Dissolution Rate of Nimodipine-HPMC Nanoparticles
Nimodipine is a dihydropyridine calcium channel blocker that shares the general properties of nifedipine, but acts mainly on cerebral blood vessels. Nimodipine belongs to the Class II Biopharmaceutical Classification System (BCS) drug group, which has low solubility and high permeability. The purpose of this study was to look at the differences in the yield of nanoparticles between the dry grinding and wet grinding methods on the physicochemical properties, solubility, and dissolution rate of nimodipine nanoparticles. The nanoparticles were prepared a nimodipine: HPMC ratio of 1:0.6 using two different methods. Sample characterization was carried out using Particle Size Analyzer (PSA), Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), X-ray Diffraction (XRD), and Fourier Transform Infrared (FT-IR). The Solubility test was carried out in CO2-free distilled water and the dissolution rate was carried out in phosphate buffer pH 7.2. The solubility of pure nimodipine in CO2-free distilled water was 0.339 µg/mL, the physical mixture was 1.948 µg/mL, the dry grinding nanoparticles were 3.367 µg/mL, and the wet grinding nanoparticles were 19.952 µg/mL. The dissolution test results obtained with the percentage of pure nimodipine dissolution at 60th minutes was 33.947%, the physical mixture was 39.482%, the dry grinding nanoparticles were 49.798%, and the wet grinding nanoparticles were 56.484%. Based on the results of the study, it can be said that the nimodipine-HPMC nanoparticles significantly increased the solubility and dissolution rate of nimodipine.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
INDONESIAN JOURNAL OF PHARMACY
INDONESIAN JOURNAL OF PHARMACY PHARMACOLOGY & PHARMACY-
CiteScore
1.20
自引率
0.00%
发文量
38
审稿时长
12 weeks
期刊介绍: The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education. The journal includes various fields of pharmaceuticals sciences such as: -Pharmacology and Toxicology -Pharmacokinetics -Community and Clinical Pharmacy -Pharmaceutical Chemistry -Pharmaceutical Biology -Pharmaceutics -Pharmaceutical Technology -Biopharmaceutics -Pharmaceutical Microbiology and Biotechnology -Alternative medicines.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信