壳聚糖基多糖生物材料在组织工程中的应用

Q4 Medicine
Azeem Azam, Shumaila Ziafat, Ata ul Mustafa Fahid, Farhan Anjum, Hamza Faseeh, Rabia Bano, Attiq ur Rehman, Amina Bashir
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引用次数: 0

摘要

壳聚糖基多糖生物材料因其独特的性能和广泛的应用前景而成为组织工程领域的可行选择。生物材料在再生医学中起着至关重要的作用,因为它们营造了一个有利于细胞生长和组织修复的环境。甲壳素衍生的多糖壳聚糖在几个方面优于合成材料:它具有与细胞外基质相似的结构,具有生物相容性,可生物降解性,抗菌性,并且可以加入生物活性化学物质。在这篇文章中,看看壳聚糖如何在组织工程中用作不同类型组织的支架,伤口愈合的水凝胶,基因治疗的载体,干细胞培养和药物输送。壳聚糖制成的支架在神经系统、骨和软骨移植以及皮肤再生的组织工程中显示出巨大的前景。壳聚糖制成的水凝胶已被证明在治疗伤口和止血方面很有用。壳聚糖在基因治疗、干细胞培养和靶向药物管理方面的药用潜力通过添加生物活性成分(如生长因子、基因或药物)进一步增强。此外,在组织工程中使用壳聚糖可以为干细胞技术、纳米技术、生物制造和3D生物打印等其他研究领域的未来发展铺平道路。这些进步可能有一天会导致组织修复和再生的个性化和高效疗法。壳聚糖在组织工程中的应用有可能促进再生医学的发展,并解决日益增长的对更有效的修复受损组织技术的需求。组织工程师可以通过利用壳聚糖的适应性和生物活性来创造尖端的生物材料和治疗技术,从而彻底改变再生医学领域,提高患者的治疗效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Application of Chitosan-Based Polysaccharide Biomaterials in Tissue Engineering
Chitosan-based polysaccharide biomaterials have gained interest as viable options in tissue engineering due to their distinctive properties and wide range of potential applications. Biomaterials play a crucial role in regenerative medicine because they foster an environment conducive to cell growth and tissue repair. The chitin-derived polysaccharide chitosan is superior than synthetic materials in several ways: it has a similar structure to the extracellular matrix, is biocompatible, biodegradable, antimicrobial, and can incorporate bioactive chemicals. In this article, check how chitosan can be used in tissue engineering as a scaffold for different types of tissue, a hydrogel for wound healing, and a carrier for gene therapy, stem cell culture, and drug delivery. Scaffolds made from chitosan have shown tremendous promise in tissue engineering for the neurological system, bone and cartilage transplantation, and skin regeneration. Hydrogels made from chitosan have been shown to be useful in treating wounds and stopping bleeding. Chitosan's medicinal potential in gene therapy, stem cell culture, and targeted medication administration is further enhanced by the addition of bioactive components such as growth factors, genes, or medicines. In addition, using chitosan in tissue engineering can pave the way for future developments in stem cell techniques, nanotechnology, biofabrication, and 3D bioprinting, among other areas of study. These advances may one day lead to individualized and highly effective therapies for tissue repair and regeneration. The use of chitosan in tissue engineering has the potential to advance regenerative medicine and address the growing demand for more effective techniques to heal damaged tissues. Tissue engineers can revolutionize the field of regenerative medicine and enhance patient outcomes by taking use of chitosan's adaptability and bioactivity to create cutting-edge biomaterials and therapeutic techniques.
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来源期刊
Pakistan Journal of Medical & Health Sciences
Pakistan Journal of Medical & Health Sciences MEDICINE, GENERAL & INTERNAL-
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期刊介绍: Pakistan Journal of Medical and Health Sciences is an international biomedical journal from Pakistan. We publish materials of interest to the practitioners and scientists in the broad field of medicine. Articles describing original qualitative, quantitative, human/animal clinical or laboratory studies are considered for publication.
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