子痫前期发病及发展过程中血清电解质变化分析

Q4 Medicine
Tamseela Mumtaz, Sania Shahid, Nageen Mustafa
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引用次数: 0

摘要

先兆子痫是妊娠期最常见的危及生命的并发症之一,与孕产妇及围产期发病率或死亡率有关。先兆子痫的一个重要原因是血压升高,这与血液中电解质的浓度直接相关。目的:探讨子痫前期孕妇体内电解质的变化。方法:将90例20 ~ 45岁的孕妇分为正常妊娠组、高血压妊娠组和子痫前期妊娠组,每组各30例。测量了所有人体测量和生物物理变量。在生化参数中,血清钠、钾、氯和钙水平采用比色法测定,而碳酸氢盐水平采用磷酸烯醇丙酮酸羧化酶和稳定的烟酰胺磷酸二氢类似物进行酶促试验测定。各组间血清电解质比较采用单因素方差分析。结果:子痫前期女性的BMI、收缩压和舒张压均明显高于高血压和正常妊娠女性(p<0.0001)。与高血压孕妇和正常孕妇相比,子痫前期孕妇的血清钠和钙浓度显著降低(p<0.0001)。结论:电解质水平的改变可能与子痫前期的发生和发展有关。限制营养钠并补充Ca +、Na +、K +和Cl +可以最大限度地降低子痫前期的风险。根据结果,建议孕妇应均衡饮食,含有适量的矿物质、微量元素和维生素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Analysis of Serum Electrolytes Variation in Onset and Progression of Preeclampsia
Preeclampsia is one of the most common, life-threatening complications of pregnancy that is related to maternal as well as perinatal morbidity or mortality. One of the significant causes of preeclampsia is elevated blood pressure which is directly linked with concentrations of electrolytes in the blood. Objective: To evaluate the possible variations of electrolytes in preeclamptic pregnant females. Methods: A total of 90 pregnant females of 20 to 45 years of age were divided into three groups (n=30 in each group) viz normotensive, hypertensive, and preeclamptic pregnant females. All anthropometric and biophysical variables were measured. Among biochemical parameters, serum sodium, potassium, chloride, and calcium levels were determined using colorimetric assays while bicarbonate levels were determined by an enzymatic test using phosphoenolpyruvate carboxylase and a stable nicotinamide dihydrogen phosphate analogue. A comparison of serum electrolytes among different groups was executed by one-way analysis of variance. Results: Preeclamptic females had significantly higher BMI, and systolic and diastolic blood pressure than hypertensive and normotensive pregnant females (p<0.0001). Serum concentrations of sodium and calcium were significantly lower in preeclamptic pregnant females compared to hypertensive pregnant and normotensive pregnant females (p<0.0001). Conclusions: Alteration in the electrolyte levels may contribute to the onset and progression of preeclampsia. Nutritional sodium restriction along with adjuvant supplementation of Ca⁺⁺, Na⁺, K⁺, and Clˉ may minimize the risk of preeclampsia. On the basis of outcomes, it is recommended that pregnant females should eat a balanced diet that contains appropriate amounts of minerals micronutrients, and vitamins.
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来源期刊
Pakistan Journal of Medical & Health Sciences
Pakistan Journal of Medical & Health Sciences MEDICINE, GENERAL & INTERNAL-
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期刊介绍: Pakistan Journal of Medical and Health Sciences is an international biomedical journal from Pakistan. We publish materials of interest to the practitioners and scientists in the broad field of medicine. Articles describing original qualitative, quantitative, human/animal clinical or laboratory studies are considered for publication.
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