Synthesis, Characterization and bioactivity Study of some new Trizole malimide Compounds

New two compounds of a five-membered heterocyclic rings triazoles compounds (T1) 4-(4,6-dioxo-5-(p-tolyl)-4,5,6,6atetrahydropyrrolo[3,4-d][1,2,3] triazol-1(3aH)-yl)benzene sulfonamide & (T2) 4-(5-(4-chlorophenyl)-4,6-dioxo-4,5,6,6atetrahydropyrrolo[3,4-d][1,2,3]triazol-1(3aH)-yl) which were synthesized by 1,3 di polar cycloaddition reaction of 4-azidobenzenesulfonamide with (A1) (1-(p-tolyl)-1H-pyrrole-2,5-dione) & (A2) (1-(4-chlorophenyl)-1Hpyrrole-2,5-dione) followed by thermal process. T1 & T2 compounds were synthesized at 56 °C in the present of acetone as a solvent. The products were recrystallized from acetone and ether (1:2), dried and characterized using Fourier transform infrared FT-IR, 1HNMR, and mass spectra. The antibacterial activities of triazoles (T1 & T2) were studied. Antibacterial and anti-fungi activity, Hole-in-plate and disk bioassay procedure methods were used to determine activity of prepared compounds (T1 & T2) against (Aspergillus Terreus,fungus & Psedomounus Aeroginosa, Kocuria Kristinie , Enterobactar Cloacae. , Aeromonase veronii and Staphylococcus Lentus) bacteria.