给药森林蜂蜜对应激大鼠皮质类固醇水平、卵泡发生和黄体数量的影响

Q3 Pharmacology, Toxicology and Pharmaceutics

Biomedical and Pharmacology Journal Pub Date : 2023-09-30 DOI:10.13005/bpj/2721

Widjiati Widjiati, Suryo Kuntjorodjakti, Aditya Tri Ananda, Mey Vanda Pusparina Sajida, Alivia Fairuz Ilmi, Meisa Zalfa Adisti, Dean Chou, Epy Muhammad Luqman

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引用次数: 0

摘要

牲畜在应激状态下会释放糖皮质激素，从而抑制下丘脑-垂体-性腺轴(HPG)信号通路，从而降低繁殖效率。森林蜂蜜可以降低糖皮质激素水平，作为生理应激诱导的应激反应，这有望提高生殖效率，包括卵泡发生和黄体的形成。本研究旨在确定森林蜂蜜对身体应激大鼠(Rattus novergicus)皮质类固醇水平、卵泡发生和黄体数量的影响。本研究为实验室实验，32只大鼠分为4个治疗组;对照阳性(C)组为物理应激组，处理1 (T1)组为物理应激+蜂蜜2 g/大鼠/天PO，处理2 (T2)组为物理应激+蜂蜜4 g/大鼠/天PO，处理3 (T3)组为物理应激+蜂蜜6 g/大鼠/天PO。所有治疗均进行14 d。结果显示，T1组皮质激素水平较各治疗组最低，且与C组和T3组相比，T1组皮质激素水平差异有统计学意义(p <0.05)。与C、T2和T3组相比，T1组的初级、次级、三级和Graafian卵泡数量有显著差异(p < 0.05)。黄体数量方面，T1组黄体数量最多，与C、T2、T3组黄体数量差异有统计学意义(p < 0.05)。由此可见，森林蜂蜜剂量为2g/大鼠/d，可降低应激大鼠体内皮质激素水平，改善卵泡发生状况，增加黄体数量。使用森林蜂蜜可以降低糖皮质激素水平，作为生理应激诱导的应激反应，有望提高生殖效率。

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The Effect of Administering Forest Honey to Rats Exposed to Physical Stress on Corticosteroid Levels, Folliculogenesis and the Number of Corpus Luteum

Livestock that has stress releases glucocorticoids in response to it, and it causes inhibition of the hypothalamus-pituitary-gonadal axis (HPG) signaling pathway so that it reduces reproductive efficiency. Forest honey can reduce corticosteroid levels as a stress response from physical stress induction which is expected to increase reproductive efficiency including folliculogenesis and the formation of the corpus luteum. This study aims to determine the effect of forest honey on rats (Rattus novergicus) exposed to physical stress on corticosteroid levels, folliculogenesis, and the number of corpus luteum. This study is an experimental laboratory one using 32 rats which were divided into 4 treatment groups; control positive (C) treated with physical stress, treatment 1 (T1) treated with physical stress + honey 2 g/rat/day PO, treatment 2 (T2) treated with physical stress + honey 4 g/rat/day PO and treatment 3 (T3) treated with physical stress + honey 6 g/rat/day PO. All treatments were carried out for 14 days. The results showed that T1 had the lowest corticosteroid level compared to all treatment groups and the corticosteroid level of this group was significantly different (p <0.05) compared to that of C and T3. The folliculogenesis profile showed that the number of primary secondary, tertiary, and Graafian follicles of group T1 was significantly different (p<0.05) compared to that of C, T2, and T3. In terms of the number of corpus luteum, it showed that T1 had the highest number of corpus luteum, and the number of corpus luteum in this group was significantly different (p<0.05) from that of C, T2, and T3. It can be concluded that the administration of forest honey at a dose of 2g/rat/day could reduce corticosteroid levels, improve the folliculogenesis profile, and increase the number of corpus luteum in rats exposed to physical stress. The use of forest honey could reduce corticosteroid levels as a stress response from physical stress induction which was expected to increase reproductive efficiency.

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来源期刊

Biomedical and Pharmacology Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

1.20

自引率

0.00%

发文量

189

期刊介绍： Biomedical and Pharmacology Journal (BPJ) is an International Peer Reviewed Research Journal in English language whose frequency is quarterly. The journal seeks to promote research, exchange of scientific information, consideration of regulatory mechanisms that affect drug development and utilization, and medical education. BPJ take much care in making your article published without much delay with your kind cooperation and support. Research papers, review articles, short communications, news are welcomed provided they demonstrate new findings of relevance to the field as a whole. All articles will be peer-reviewed and will find a place in Biomedical and Pharmacology Journal based on the merit and innovativeness of the research work. BPJ hopes that Researchers, Research scholars, Academician, Industrialists etc. would make use of this journal for the development of science and technology. Topics of interest include, but are not limited to: Biochemistry Genetics Microbiology and virology Molecular, cellular and cancer biology Neurosciences Pharmacology Drug Discovery Cardiovascular Pharmacology Neuropharmacology Molecular & Cellular Mechanisms Immunology & Inflammation Pharmacy.