纳米粒子-化疗中蓬勃发展的药物输送系统

Q3 Pharmacology, Toxicology and Pharmaceutics

Biomedical and Pharmacology Journal Pub Date : 2023-09-30 DOI:10.13005/bpj/2757

Shalu Verma, Alka Singh, Gauree Kukreti, Meenakshi Bharkatiya, Kiran Dobhal, Tarun Parashar, Jyotsana Suyal, Vikash Jakhmola

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引用次数: 0

摘要

目前的研究提出了“纳米颗粒-一种在化疗中蓬勃发展的药物递送系统”是一种新的靶向方法，通过减少剂量相关的副作用和患者的死亡率来提高化疗药物的疗效，因为它具有非免疫原性和无毒性。药物的生物利用度、药物的溶解度、药物的生物分布、治疗引起的耐药以及非特异性毒性等都可以随着纳米技术的发展而得到改善。它具有主动和被动靶向肿瘤细胞。因此，顺铂、紫杉醇、阿霉素、卡铂等多种化疗药物被广泛用于治疗癌症。研究发现，纳米颗粒对深层组织的渗透可以增强渗透和保留(EPR)效应。传统的给药系统存在一些局限性，利用纳米颗粒作为给药系统可以最大限度地减少这些局限性。目前的综述主要集中在靶向策略和纳米颗粒治疗癌症的新方法。

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Nanoparticles – A Booming Drug Delivery System in Chemotherapy

The current study proposed the “Nanoparticles -A Booming Drug Delivery System in Chemotherapy” is a Novel targeted approach which enhances the efficacy of chemotherapeutic agents by reducing the dose-related side effect as well as mortality rate a in patients due to its non-immunogenic, nontoxic nature. Drug bioavailability, drug solubility, drug biodistribution, drug resistance brought on by treatment, and nonspecific toxicity can all be improved with the development of nanoparticle chemotherapeutic drug delivery applications based on nanotechnology. It possesses active as well as passive targeting of tumour cells. Due to this reason, a wide range of chemotherapeutic agents like cisplatin, taxol, doxorubicin, and carboplatin are extensively utilized for treating cancer. Deep tissue penetration of nanoparticles is found to increase the enhanced permeability and retention (EPR) effect. There are some limitations with conventional drug delivery system which is minimized by utilizing nanoparticles as a drug delivery system. The current review has focused on targeted strategies and novel approaches in cancer treatment with nanoparticles.

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来源期刊

Biomedical and Pharmacology Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

1.20

自引率

0.00%

发文量

189

期刊介绍： Biomedical and Pharmacology Journal (BPJ) is an International Peer Reviewed Research Journal in English language whose frequency is quarterly. The journal seeks to promote research, exchange of scientific information, consideration of regulatory mechanisms that affect drug development and utilization, and medical education. BPJ take much care in making your article published without much delay with your kind cooperation and support. Research papers, review articles, short communications, news are welcomed provided they demonstrate new findings of relevance to the field as a whole. All articles will be peer-reviewed and will find a place in Biomedical and Pharmacology Journal based on the merit and innovativeness of the research work. BPJ hopes that Researchers, Research scholars, Academician, Industrialists etc. would make use of this journal for the development of science and technology. Topics of interest include, but are not limited to: Biochemistry Genetics Microbiology and virology Molecular, cellular and cancer biology Neurosciences Pharmacology Drug Discovery Cardiovascular Pharmacology Neuropharmacology Molecular & Cellular Mechanisms Immunology & Inflammation Pharmacy.