壳聚糖对以纤维素为基础的葎草提取物皮肤制剂理化性质的影响

IF 0.8 Q4 MATERIALS SCIENCE, BIOMATERIALS

Progress on Chemistry and Application of Chitin and its Derivatives Pub Date : 2023-09-30 DOI:10.15259/pcacd.28.003

Bożena Grimling

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引用次数: 0

摘要

本研究评价了含有Celugel、3%酒花锥提取物(采用超临界二氧化碳提取底物)和1%和2%壳聚糖的水凝胶用于皮肤病学治疗炎症性皮肤状况。壳聚糖的存在显著影响了配方的流变性能，包括动态粘度、硬度、稠度、黏结性和模糊时间。含2%壳聚糖的配方应用前景最好。对这些配方的溶出度进行了评价，这是一种类似于啤酒花提取物中所含的葎草酮。壳聚糖的浓度对活性成分的溶出测试参数有显著影响:随着壳聚糖浓度的增加，在保持凝胶成膜性能的同时，达到了延长活性成分释放时间的预期效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

THE EFFECT OF CHITOSAN ON THE PHYSICOCHEMICAL PROPERTIES OF DERMATOLOGICAL PREPARATIONS CONTAINING HUMULUS LUPULUS L. EXTRACT BASED ON CELUGEL

This study evaluated hydrogels containing Celugel, 3% hop cone extract obtained from Humulus lupulus L. using supercritical carbon dioxide extraction substrate, and 1% and 2% chitosan for dermatological application to treat inflammatory skin conditions. The presence of chitosan significantly affected the rheological properties of the formulations, including their dynamic viscosity, hardness, consistency, cohesiveness, and blurring time. The formulations containing 2% chitosan showed the best application possibilities. The formulations were evaluated for dissolution of cohumulone, which is an analogue of humulone contained in hop cone extract. The concentration of chitosan in the formulations had a significant effect on the dissolution testing parameters of the active ingredient: as the chitosan concentration increased, the desired effect of prolonged release time of the active ingredient was achieved while maintaining the membrane-forming properties of Celugel.

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来源期刊

Progress on Chemistry and Application of Chitin and its Derivatives MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

1.10

自引率

16.70%

发文量

期刊介绍： Progress in the Chemistry and Application of Chitin and its Derivatives is an annual journal focused on all aspects of production, modification, enzymology and application of chitin and its many derivatives, including chitosan. The journal publishes full-length papers as well as invited reviews. To be considered, papers must present original research that has not been published or accepted for publication elsewhere. The language of the journal will be English.