DNA纳米材料在癌症诊断和治疗中的最新进展

IF 6.1 3区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Longjie Li, Zhen Wang, Xuehao Zhang, Yukai Deng, Yaoqin Mu, Jingrou Li, Li-mei Wang, Hong-xun Wang, Junlin Zhang, Hengyi Gao, Yajie Mao
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引用次数: 0

摘要

沃森和克里克对脱氧核糖核酸(DNA)结构特征的阐明,聚合酶链反应技术的出现以及引物合成方法的发展,使DNA的复制和转化变得越来越容易,使其成为分子生物学中最具方向性和进化性的纳米材料之一。传统的癌症诊断方法有一定的局限性,不能满足现有的需求;因此,具有广泛特性的DNA纳米结构正受到越来越多的关注,因为许多DNA材料已被证明具有诊断特性。一些DNA材料可以在功能上改变细胞的生物学行为,如细胞迁移、细胞增殖、细胞分化、自噬和抗炎作用。一些通过自配对形成二级结构的单链DNA或核糖核酸,称为适体(aptamer),配体的指数富集系统进化(SELEX)具有靶向能力,可用于肿瘤的靶向诊断和治疗。几种具有三维纳米结构和稳定结构的DNA纳米材料正被研究作为药物载体系统作用于各种抗肿瘤药物或基因治疗药物。本文综述了功能化DNA纳米结构在癌症诊断和治疗中的应用。介绍了基于DNA纳米结构的各种生物传感器和载体,并讨论了与载体制备相关的化学反应和传感器的信号转导机制。本文还介绍了基于各种结构发展和当前DNA纳米材料发展的高效载体/生物传感器平台。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recent advances in DNA nanomaterials for cancer diagnosis and treatment
Abstract The elucidation of the structural characteristics of deoxyribonucleic acid (DNA) by Watson and Crick, the advent of polymerase chain reaction technology, and the development of primer-synthesis methods, enable DNA to be replicated and transformed in an increasingly easy manner, such that it is among the most directed and evolving nanomaterials in molecular biology. Traditional cancer diagnosis methods are somewhat limited and are unable to meet existing needs; consequently, DNA nanostructures with wide ranging properties are receiving increasingly more attention because a number of DNA materials have been shown to exhibit diagnostic properties. Some DNA materials can functionally alter the biological behavior of cells, such as cell migration, cell proliferation, cell differentiation, autophagy, and anti-inflammatory effects. Some single-stranded DNA or ribonucleic acid with secondary structure through self-pairing, called aptamer, systematic evolution of ligands by exponential enrichment (SELEX), have targeting capabilities and can be applied to tumor targeted diagnosis and therapy. Several DNA nanomaterials with three-dimensional nanostructures and stable structures are being investigated as drug carrier systems to act on a variety of antitumor drugs or gene therapy agents. This article reviews the use of functionalized DNA nanostructures in cancer diagnosis and treatment applications. Various biosensors and carriers based on DNA nanostructures are introduced and chemical reactions related to the preparation of the carrier and the signal transduction mechanism of the sensor are discussed. Efficient carrier/biosensor platforms based on various structural developments and current DNA nanomaterial developments are also presented.
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来源期刊
Nanotechnology Reviews
Nanotechnology Reviews CHEMISTRY, MULTIDISCIPLINARY-NANOSCIENCE & NANOTECHNOLOGY
CiteScore
11.40
自引率
13.50%
发文量
137
审稿时长
7 weeks
期刊介绍: The bimonthly journal Nanotechnology Reviews provides a platform for scientists and engineers of all involved disciplines to exchange important recent research on fundamental as well as applied aspects. While expert reviews provide a state of the art assessment on a specific topic, research highlight contributions present most recent and novel findings. In addition to technical contributions, Nanotechnology Reviews publishes articles on implications of nanotechnology for society, environment, education, intellectual property, industry, and politics.
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