半固体剂型甲硝唑、利多卡因、咪康唑的反相高效液相色谱测定方法设计分析质量

IF 2.8 3区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Journal of Taibah University for Science Pub Date : 2023-09-13 DOI:10.1080/16583655.2023.2252593

Viswanathan Sukumar, Hemanth Kumar Chanduluru, Saravanan Chinnusamy

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引用次数: 1

摘要

建立了一种基于AQbD和GAC的反相高效液相色谱法同时测定椭圆剂型甲硝唑(MET)、利多卡因(LID)和咪康唑(MIC)的分析方法。在固定相Zorbax C18 150 mm × 4.6 mm (i.d)上进行分离;5 μm，采用含有乙醇和磷酸盐缓冲液的梯度流动相。MET浓度为240 ~ 390 μg/mL, LID浓度为32 ~ 52 μg/mL, MIC浓度为64 ~ 104 μg/mL，其检出限和检出限分别为31.25、94.705 μg/mL (MIC)、1.463、4.433 μg/mL (LID)和7.981、24.187 μg/mL。最后，使用这三种工具对绿色度进行评估的方法表明，所开发的方法是生态友好的。所开发的方法简单可靠，具有有助于进一步改进的设计空间，并且是环保的，使该方法在常规质量控制分析中采用独特的方法。

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Ecofriendly analytical quality by design-based method for determining Metronidazole, Lidocaine and Miconazole using RP-HPLC in semisolid dosage form

The article deals with the development of an analytical method based on AQbD and GAC for the simultaneous determination of Metronidazole (MET), Lidocaine (LID) and Miconazole (MIC) in oval dosage form using RP-HPLC. The separation was achieved on the stationary phase Zorbax C18 150 mm × 4.6 mm (i.d); 5 μm, using a gradient mobile phase containing Ethanol and Phosphate buffers. The linearity has been obtained for MET's 240-390 μg/mL, 32-52 μg/mL for LID and 64-104 μg/mL for MIC, with their LOD and LOQ as 31.25, 94.705 μg/mL (MIC) 1.463, 4.433 μg/mL (LID) and 7.981, 24.187 μg/mL for MIC, respectively. Finally, the method assessed for greenness using the three tools showed that the developed method was eco-friendly. The developed method is simple and reliable with a design space that helps for further improvement and is eco-friendly, making this method unique for adoption in regular quality control analysis.

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来源期刊

Journal of Taibah University for Science MULTIDISCIPLINARY SCIENCES-

CiteScore

6.60

自引率

6.10%

发文量

102

审稿时长

19 weeks

期刊介绍： Journal of Taibah University for Science (JTUSCI) is an international scientific journal for the basic sciences. This journal is produced and published by Taibah University, Madinah, Kingdom of Saudi Arabia. The scope of the journal is to publish peer reviewed research papers, short communications, reviews and comments as well as the scientific conference proceedings in a special issue. The emphasis is on biology, geology, chemistry, environmental control, mathematics and statistics, nanotechnology, physics, and related fields of study. The JTUSCI now quarterly publishes four issues (Jan, Apr, Jul and Oct) per year. Submission to the Journal is based on the understanding that the article has not been previously published in any other form and is not considered for publication elsewhere.