姑息治疗中癌症患者的缺铁性贫血

Orkun SARIÇAM, Gülhan SARIÇAM
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摘要

在本研究中,我们旨在通过比较贫血严重程度与肿瘤患者转移、功能表现、摄食状况等预后因素,探讨贫血对预后的影响。本研究纳入189名在姑息治疗单位(PCU)接受治疗的癌症患者。记录患者的人口学特征、贫血试验结果、化疗、转移状态、功能表现、住院时间和出院状态,并在研究组之间进行比较。在PCU的癌症患者中,85.7%有贫血,88.4%有转移。在重度贫血患者中,东部肿瘤合作组量表(ECOG)评分较低,c反应蛋白(CRP)水平明显高于其他组患者(p=0.045, p=0.000)。发现中度贫血患者的格拉斯哥昏迷量表(GCS)明显低于无贫血患者。(p=0.049)我们已经表明,在PCU治疗的晚期癌症患者中,贫血的严重程度与预后不良标准(包括低ECOG、GCS评分和高CRP水平)之间存在相关性。在癌症患者的病程中,应确保早期评估贫血和摄入足够的营养以及补充铁。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Iron Deficiency Anemia in Cancer Patients in Palliative Care
In this study, we aimed to investigate the effects of anemia on the prognosis by comparing the severity of anemia with several prognostic factors including metastases, functional performance, and the feeding status of cancer patients.This study included 189 cancer patients, who received treatment in the palliative care unit (PCU). Demographic characteristics of the patients, anemia test panel results, chemotherapy, the status of metastases, functional performance, the length of hospital stay, and the status at discharge were recorded and compared between the study groups. Of the cancer patients in PCU, 85.7% had anemia and 88.4% had metastases. In patients with severe anemia, the Eastern Cooperative Oncology Group Scale (ECOG) performance scores were lower and C-reactive protein (CRP) levels were significantly higher compared to the other patients in other groups (p=0.045, p=0.000). Glasgow Coma Scales (GCS) were found to be significantly lower in patients with moderate anemia than those without anemia. (p=0.049) We have shown that there is a correlation between the severity of anemia and poor prognostic criteria including low ECOG, GCS scores and high CRP levels in advanced cancer patients we treated in PCU. The early assessment of anemia and the adequate intake of nutrients along with iron supplements should be ensured in cancer patients during the disease course.
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