microrna作为良性增生和前列腺癌分化的分子生物学标志物

Z. M. Akhokhov, R. S. Ismailov, M. I. Kogan
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引用次数: 0

摘要

前列腺癌的诊断和治疗与血清前列腺特异性抗原(PSA)水平相关。然而,某些前列腺疾病,如良性前列腺增生(BPH)和前列腺炎也会影响PSA水平。PSA的低特异性和敏感性导致“不必要的”前列腺活检,这当然使这种诊断方法成为一个有争议的筛选试验。因此,发现新的无创分子生物学标志物对前列腺疾病患者的诊断、治疗、监测和预后具有重要意义。本文旨在评价mirna作为BPH和PCa分化的分子生物学标志物的“益处”。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
MicroRNAs as molecular biological markers of benign hyperplasia and prostate cancer differentiation
Diagnosis and treatment of prostate cancer (PCа) are associated with the serum level of prostate specific antigen (PSA). However, certain prostate diseases such as benign prostatic hyperplasia (BPH) and prostatitis can also affect PSA levels. The low specificity and sensitivity of PSA leads to a "unnecessary" prostate biopsy, which certainly makes this diagnostic method a controversial screening test. As a result, the discovery of new non-invasive molecular biological markers are necessary for the diagnosis, treatment, surveillance and prognosis of patients with diseases of prostate. This review aims to evaluate the "benefit" of miRNAs as molecular biological markers of BPH and PCa differentiation.
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