{"title":"中介路径分析中复合零假设的自适应自举检验","authors":"Yinqiu He, Peter X K Song, Gongjun Xu","doi":"10.1093/jrsssb/qkad129","DOIUrl":null,"url":null,"abstract":"Abstract Mediation analysis aims to assess if, and how, a certain exposure influences an outcome of interest through intermediate variables. This problem has recently gained a surge of attention due to the tremendous need for such analyses in scientific fields. Testing for the mediation effect (ME) is greatly challenged by the fact that the underlying null hypothesis (i.e. the absence of MEs) is composite. Most existing mediation tests are overly conservative and thus underpowered. To overcome this significant methodological hurdle, we develop an adaptive bootstrap testing framework that can accommodate different types of composite null hypotheses in the mediation pathway analysis. Applied to the product of coefficients test and the joint significance test, our adaptive testing procedures provide type I error control under the composite null, resulting in much improved statistical power compared to existing tests. Both theoretical properties and numerical examples of the proposed methodology are discussed.","PeriodicalId":49982,"journal":{"name":"Journal of the Royal Statistical Society Series B-Statistical Methodology","volume":null,"pages":null},"PeriodicalIF":3.1000,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Adaptive bootstrap tests for composite null hypotheses in the mediation pathway analysis\",\"authors\":\"Yinqiu He, Peter X K Song, Gongjun Xu\",\"doi\":\"10.1093/jrsssb/qkad129\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract Mediation analysis aims to assess if, and how, a certain exposure influences an outcome of interest through intermediate variables. This problem has recently gained a surge of attention due to the tremendous need for such analyses in scientific fields. Testing for the mediation effect (ME) is greatly challenged by the fact that the underlying null hypothesis (i.e. the absence of MEs) is composite. Most existing mediation tests are overly conservative and thus underpowered. To overcome this significant methodological hurdle, we develop an adaptive bootstrap testing framework that can accommodate different types of composite null hypotheses in the mediation pathway analysis. Applied to the product of coefficients test and the joint significance test, our adaptive testing procedures provide type I error control under the composite null, resulting in much improved statistical power compared to existing tests. Both theoretical properties and numerical examples of the proposed methodology are discussed.\",\"PeriodicalId\":49982,\"journal\":{\"name\":\"Journal of the Royal Statistical Society Series B-Statistical Methodology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2023-11-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the Royal Statistical Society Series B-Statistical Methodology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/jrsssb/qkad129\",\"RegionNum\":1,\"RegionCategory\":\"数学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"STATISTICS & PROBABILITY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Royal Statistical Society Series B-Statistical Methodology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/jrsssb/qkad129","RegionNum":1,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"STATISTICS & PROBABILITY","Score":null,"Total":0}
Adaptive bootstrap tests for composite null hypotheses in the mediation pathway analysis
Abstract Mediation analysis aims to assess if, and how, a certain exposure influences an outcome of interest through intermediate variables. This problem has recently gained a surge of attention due to the tremendous need for such analyses in scientific fields. Testing for the mediation effect (ME) is greatly challenged by the fact that the underlying null hypothesis (i.e. the absence of MEs) is composite. Most existing mediation tests are overly conservative and thus underpowered. To overcome this significant methodological hurdle, we develop an adaptive bootstrap testing framework that can accommodate different types of composite null hypotheses in the mediation pathway analysis. Applied to the product of coefficients test and the joint significance test, our adaptive testing procedures provide type I error control under the composite null, resulting in much improved statistical power compared to existing tests. Both theoretical properties and numerical examples of the proposed methodology are discussed.
期刊介绍:
Series B (Statistical Methodology) aims to publish high quality papers on the methodological aspects of statistics and data science more broadly. The objective of papers should be to contribute to the understanding of statistical methodology and/or to develop and improve statistical methods; any mathematical theory should be directed towards these aims. The kinds of contribution considered include descriptions of new methods of collecting or analysing data, with the underlying theory, an indication of the scope of application and preferably a real example. Also considered are comparisons, critical evaluations and new applications of existing methods, contributions to probability theory which have a clear practical bearing (including the formulation and analysis of stochastic models), statistical computation or simulation where original methodology is involved and original contributions to the foundations of statistical science. Reviews of methodological techniques are also considered. A paper, even if correct and well presented, is likely to be rejected if it only presents straightforward special cases of previously published work, if it is of mathematical interest only, if it is too long in relation to the importance of the new material that it contains or if it is dominated by computations or simulations of a routine nature.